Review Artikel: Memperbaiki Permeabilitas Obat Bcs Kelas II, III Dan IV Dengan Metode Ko-Amorf

Vicania Raisa Rahman (Program Studi Profesi Apoteker, Fakultas Farmasi, Universitas Padjadjaran, Sumedang, Jawa Barat, Indonesia.)
Arif Budiman (Program Studi Profesi Apoteker, Fakultas Farmasi, Universitas Padjadjaran, Sumedang, Jawa Barat, Indonesia.)

Journal of Pharmaceutical and Sciences.
JPS Volume 6 Nomor 1 (2023)

Drugs in the co-amorphous form are combinations of amorphous drugs with co-formers that have good solubility and stability so that dissolution becomes better and influences the therapeutic effect of drugs better, too the first time a co-amorphous formulation was made to overcome the low solubility of BCS class II. However, the current study found that co-amorphous formulations could improve solubility and the permeability of BCS class III and IV drugs. Co-amorphous production methods include cryo-milling, melting and quench cooling, solvent evaporation, and spray drying. This article review was conducted to gather information about BCS class II, III, and IV drugs made in co-amorphous forms to improve the physicochemical properties of drugs, such as solubility, permeability, and stability. Articles were collected from 20 research journals published over the last ten years. The co-amorphous drug testing of 10 drugs showed higher solubility and permeability than in crystal form