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Vicania Raisa Rahman
Program Studi Profesi Apoteker, Fakultas Farmasi, Universitas Padjadjaran, Sumedang, Jawa Barat, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Review Artikel: Memperbaiki Permeabilitas Obat Bcs Kelas II, III Dan IV Dengan Metode Ko-Amorf Vicania Raisa Rahman; Arif Budiman
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.825 KB) | DOI: 10.36490/journal-jps.com.v6i1.68

Abstract

Drugs in the co-amorphous form are combinations of amorphous drugs with co-formers that have good solubility and stability so that dissolution becomes better and influences the therapeutic effect of drugs better, too the first time a co-amorphous formulation was made to overcome the low solubility of BCS class II. However, the current study found that co-amorphous formulations could improve solubility and the permeability of BCS class III and IV drugs. Co-amorphous production methods include cryo-milling, melting and quench cooling, solvent evaporation, and spray drying. This article review was conducted to gather information about BCS class II, III, and IV drugs made in co-amorphous forms to improve the physicochemical properties of drugs, such as solubility, permeability, and stability. Articles were collected from 20 research journals published over the last ten years. The co-amorphous drug testing of 10 drugs showed higher solubility and permeability than in crystal form
Co-Authors Arif Budiman