Uji aktivitas antihiperurisemia ekstrak daun kopasanda (Chromolaena Odorata (L.) R.M.King & H.Rob terhadap mencit putih jantan (Mus Musculus L.) yang diinduksi kalium oxonat

Asyrun Alkhairi Lubis (Program Studi Farmasi Klinis, Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan, Universitas Prima Indonesia. Medan, Sumatera Utara, Indonesia.)
Muhammad Yunus (Program Studi Farmasi Klinis, Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan, Universitas Prima Indonesia. Medan, Sumatera Utara, Indonesia.)
Jefri Naldi (Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia, Medan, Indonesia.)
Muhammad Andry (Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia, Medan, Indonesia.)
Pricella Ginting (Program studi Farmasi, Fakultas Farmasi Dan Kesehatan, Institut Kesehatan Helvetia, Medan, Indonesia)
Fira Safitri (Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia, Medan, Indonesia.)
Muhammad Amin Nasution (Program Studi Farmasi, Fakultas Farmasi, Universitas Muslim Nusantara al Washliyah, Medan, Indonesia)

Journal of Pharmaceutical and Sciences.
JPS Volume 6 Nomor 3 (2023)

Background: Kopasanda leaves (Chromolaena Odorata (L.) R.M.King & H.Rob have been known as medicinal plants and spread in North America, Asia, West Africa and Australia have antibacterial and antioxidant properties, because the active compounds contained in Kopasanda leaves include: alkaloids, flavonoids, steroids, quinone saponins, and tannins. Purpose; This study was to determine the activity of ethanol extract of kopasanda leaves (Chormolaena Odorata (L.) in reducing uric acid levels and to test antihyperuricemia levels and phytochemical screening. Method; This study used a laboratory experimental research design, to extract the chemical content in kopasanda leaves using maceration method using 70% ethanol. This research includes sampling, simplisia making, extract making, phytokimi screening, suspension making, test animal preparation and antihyperuricemia testing. The research data were analyzed using the crucible wallis test statistical test. Result; The study showed a decrease in uric acid levels in the EEDK group 20 mg / BB = 0.86%, EEDK 40 mg / BB = 1.18% and EEDK 80 mg / BB = 2.3%. The results of Wallis' crucial statistical test on day 9 showed a significant difference with a p-value of 0.000. The results of further difference tests showed a significant difference in each treatment. Conclusion: in this study is the ethanol extract of kopasanda leaves (Chromolaena Odorata (L), R.M.King &; H. Rob) the most effective is 80 mg / BB, this is evidenced by the results of one way anova statistical test with a p-value of 0.000 (<0.05).