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All Journal Ranah Research : Journal of Multidisciplinary Research and Development Journal of Pharmaceutical and Sciences.
Muhammad Yunus
Prodi Apoteker Universitas Prima Indonesia, Medan. Sumatera Utara, Indonesia.
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Drug-related problem (DRP) penggunaan antidiabetik oral dan insulin pada pasien diabetes melitus tipe II rawat inap di RSU Royal Prima Medan Elfia Neswita; Brian Elberth Halu; Razoki; Asyrun lkhairi Lubis; Muhammad Yunus; Nurasni; Octavian Ashido Nababan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.186

Abstract

Diabetes mellitus is a group of metabolic disorders characterised by hyperglycemia which is the cause of death of up to 80% in low- and middle-income countries. Type 2 diabetes mellitus is the most common form of diabetes. The goals of managing type 2 diabetes mellitus therapy are to reduce the risk of microvascular and macrovascular complications, reduce mortality, and improve quality of life. Treatment of diabetes mellitus requires a long time. Problems arising from complications in diabetes mellitus will increase the difficulty in treating patients. This can potentially cause issues related to Drug Related Problems (DRP). Drug-Related Problems refers to unexpected events experienced by patients and can interfere with the success of the drug therapy given. The research method in this study was to determine the drugs to be evaluated in the form of oral antidiabetic drugs used while undergoing type 2 diabetes mellitus therapy and insulin therapy. The results showed that 26 patients experienced Drug-Related Problems or not (50%). Six patients experienced actual Drug Related Problems (10.2%). In comparison, those who experienced Potential Drug Related Problems were 24 patients (46.15%) of a total of 52 patients with type 2 diabetes mellitus who were the sample of this study. Two categories of Drug Related Problems occur, namely Drug Related Problems related to additional drug therapy with a total of 2 incidents (2.17%) and Drug Related Problems related to unwanted drug reactions (Adverse Drug Reactions) with a total of 4 incidents (7,7%).  
Uji aktivitas diuretik ekstrak etanol daun sirih merah (Piper crocatum Ruiz & Pav) terhadap tikus putih jantan (Rattus novergicus) Muhammad Yunus; Jefri Naldi; Muhammad Andry
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.195

Abstract

Background: According to the World Health Organization (WHO), the prevalence of hypertension in the world reached over 1.13 billion people in 2015, implying that one out of every three persons was diagnosed with hypertension. Flavonoids found in red betel leaves (Piper crocatum Ruiz & Pav) serve as antifungals, diuretics, antihistamines, antihypertensives, insecticides, bactericidal, antiviral, and enzyme inhibitors. The study aimed to find the best dose of red betel leaves extract as a diuretic in male white rats. The study was experimental laboratory. Alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids are among the phytochemicals tested. A total of 25 male white rats were separated into five groups. Red betel leaves extract was administered to groups 1, 2, and 3 at dosages of 250mg/kg, 350 mg/kg, and 650mg/kg, respectively. Group 4 received a 0.5% Na CMC suspension as a negative control, while Group 5 received a furosemide suspension as a positive control. The average urine volume at 1-6 hours and the buildup of urine were used to calculate the rat urine volume. The results showed the accumulation of urine volume for 6 hours. The treatment group of red betel leaf ethanol extract at a dose of 250mg/kgBW obtained 0.57mL, a dose of 350mg/kgBW obtained 2.38mL, and a dose of 650mg/kgBW obtained 4.29mL, negative control (CMC 0.5%) obtained 0.2mL, positive control obtained 27.52mL. The study concluded that red betel leaves extract has diuretic action and that the ethanol extract of red betel leaves at a dosage of 650 mg/kgBW is the most effective dose.
Uji aktivitas antihiperurisemia ekstrak daun kopasanda (Chromolaena Odorata (L.) R.M.King & H.Rob terhadap mencit putih jantan (Mus Musculus L.) yang diinduksi kalium oxonat Asyrun Alkhairi Lubis; Muhammad Yunus; Jefri Naldi; Muhammad Andry; Pricella Ginting; Fira Safitri; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.209

Abstract

Background: Kopasanda leaves (Chromolaena Odorata (L.) R.M.King & H.Rob have been known as medicinal plants and spread in North America, Asia, West Africa and Australia have antibacterial and antioxidant properties, because the active compounds contained in Kopasanda leaves include: alkaloids, flavonoids, steroids, quinone saponins, and tannins. Purpose; This study was to determine the activity of ethanol extract of kopasanda leaves (Chormolaena Odorata (L.) in reducing uric acid levels and to test antihyperuricemia levels and phytochemical screening. Method; This study used a laboratory experimental research design, to extract the chemical content in kopasanda leaves using maceration method using 70% ethanol. This research includes sampling, simplisia making, extract making, phytokimi screening, suspension making, test animal preparation and antihyperuricemia testing. The research data were analyzed using the crucible wallis test statistical test. Result; The study showed a decrease in uric acid levels in the EEDK group 20 mg / BB = 0.86%, EEDK 40 mg / BB = 1.18% and EEDK 80 mg / BB = 2.3%. The results of Wallis' crucial statistical test on day 9 showed a significant difference with a p-value of 0.000. The results of further difference tests showed a significant difference in each treatment. Conclusion: in this study is the ethanol extract of kopasanda leaves (Chromolaena Odorata (L), R.M.King &; H. Rob) the most effective is 80 mg / BB, this is evidenced by the results of one way anova statistical test with a p-value of 0.000 (<0.05).
Uji Efek Antihiperglikimia Fraksi Aktif Ekstrak Etanol Daun Sirsak (Annona Muricata) dan Ekstrak Ikan Gabus (Channa Striata) pada Tikus Razoki Razoki; Cindy Ronaldo Munthe; Reh Malem Br Karo; Muhammad Yunus; Asyrun Alkhaira Lubis
Ranah Research : Journal of Multidisciplinary Research and Development Vol. 6 No. 4 (2024): Ranah Research : Journal Of Multidisciplinary Research and Development (Mei 202
Publisher : Dinasti Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/rrj.v6i4.919

Abstract

Tujuan penlitian ini adalah untuk mengetahui efektivitas antihiperglikemia pada tumbuhan daun sirsak (annona muricata) sebagai terapi diabetes mellitus. Ekstrak di maserasi menggunakan pelrut ethanol 96%. Hasil skrining fitokimia menunjukan bahwa pada daun sirsak (annona muricata) mengandung senyawa alkaloid, flavonoid, saponin, tanin dan steroid/triterpenoid. Kemudian di lanjutkan proses fraksinasi ekstrak daun sirsak (annona muricata) untuk memperoleh fraksi aktif ekstrak etanol daun sirsak (annona muricata) dengan partisi cair-cair menggunakan pelarut n-heksan:etanol 96% = 1:1. Pengujian antihiperglikemia menggunakan hewan percobaan tikus puith jantan galur wistar. Konsentrasi kelompok Pada perlaukan pertama tidak diberikan perlakuan atau sebagai kelompok kontrol negatif, kelompok kedua diberikan perlakuan berupa pemberian fraksi ethanol ekstrak daun sirsak dengan dosis 200 mg/kg BB, kelompok ketiga diberikan ekstrak ikan gabus dengan dosis 250 mg/kg BB, kelompok keempat yang diberikan kombinasi fraksi ethanol ekstrak sirsak 200 mg/kg BB dan ekstak ikan gabus 250 mg/kg BB. Kelompok kelima yang diberikan kombinasi fraksi ethanol ekstrak daun sirsak 400 mg/kg BB dengan ekstrak ikan gabus 250 mg/kg BB. Lalu pada kelompok keenam diberikan kombinasi fraksi ethanol ekstrak daun sirsak 800 mg/kg BB dengan eksrak ikan gabus 250 mg/kg BB. Hasil paling besar dalam menurunkan kadar gula darah tikus pada kelompok keenam diberikan kombinasi fraksi ethanol ekstrak daun sirsak 800 mg/kg BB dengan eksrak ikan gabus 250 mg/kg BB dengan nilai rerata penurunan -25,54 %, Kelompok kelima yang diberikan kombinasi fraksi ethanol ekstrak daun sirsak 400 mg/kg BB dengan ekstrak ikan gabus 250 mg/kg BB dengan nilai penurun -3,65%, kelompok kedua diberikan perlakuan berupa pemberian fraksi ethanol ekstrak daun sirsak dengan dosis 200 mg/kg BB dengan nilai rerata penurunan -2,96%. Dan menunjukan bahwa penurunan kadar gula darah terbesar pada tikus jantan galur wistar yang di induksi glukosa 40% yaitu pada pada kelompok keenam diberikan kombinasi fraksi ethanol ekstrak daun sirsak 800 mg/kg BB dengan eksrak ikan gabus 250 mg/kg BB dengan nilai rerata penurunan -25,54 %.
Co-Authors Asyrun Alkhaira Lubis Asyrun Alkhairi Lubis Asyrun lkhairi Lubis Brian Elberth Halu Cindy Ronaldo Munthe Elfia Neswita Fira Safitri Jefri Naldi Jefri Naldi Muhammad Amin Nasution Muhammad Andry Nurasni Octavian Ashido Nababan Pricella Ginting Razoki Razoki Razoki Reh Malem Br Karo