Chemistry Indonesian Journal of Chemical Research
Vol 11 No 2 (2023): Edition for September 2023

Synthesis, Evaluation, and Molecular Docking Study of 4-Monoacyl Resorcinol Against Tyrosinase Enzyme

Danova, Ade (Unknown)
Maulana, Yusuf Eka (Unknown)
Hermawati, Elvira (Unknown)
Chavasiri, Warinthorn (Unknown)

Article Info

Publish Date
22 Sep 2023

Abstract

Tyrosinase is a crucial enzyme in melanin production to protect the skin from ultraviolet, leading to skin cancers. This study synthesized eight compounds of acyl resorcinol with long-chain carbon (1-8) and structurally elucidated by 1H and 13C NMR. The in vitro evaluation of eight synthesized compounds against tyrosinase enzyme showed that 4-heptanoyl resorcinol (6) exhibited high inhibitory activity compared with the kojic acid as standard. In addition, the molecular docking study demonstrated that 6 showed lower binding energy (-7.3 kcal/mol) than kojic acid (-6.9 kcal/mol) and possessed interaction with crucial residues in the active site.

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Journal Info
Chemistry Indonesian Journal of Chemical Research
Website

Abbrev

Indonesian Journal of Chemical Research (Indones.

Publisher

Universitas Pattimura

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Engineering Environmental Science

Description

Indo. J. Chem. Res. is a journal that regularly publishes primary articles covering all branches of chemistry and its sub-disciplines. Published articles consist of complete research, short communication, and review articles. The scope of published articles is not limited to inorganic chemistry, ...