JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
JKKI, Vol 14, No 2, (2023)

A male Covid-19 convalescent plasma donor with long existence of SARS-Cov-2 antibodies: a case report

Teguh Triyono (Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Sleman, Indonesia)
Usi Sukorini (Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Sleman, Indonesia)
Andri Christianalusi (Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Sleman, Indonesia)
Sri Mulatsih (Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Sleman, Indonesia)
Hans Vrielink (University of Amsterdam, Amsterdam, Netherlands)



Article Info

Publish Date
31 Aug 2023

Abstract

Covid-19 Convalescent Plasma (CCP) was one of alternative therapy for Covid-19 patients. The use of convalescent plasma as an adjunct therapy must consider its efficacy, benefits, and risk, both for the patient and the donor. Convalescent Plasma was produced from purified human plasma. Convalescent Plasma was a passive immunity which provide active antibodies. CCP give immunity to the patient through the transfusion of a survivor’s antibodies. We were reporting a case of male CCP donor with long existence of SARS-Cov-2. This donor performed up to 16 donations, which was an unusual case in CCP donor. The SARS-CoV-2 antibody titer was analyzed using Elecsys® Anti-SARS-CoV-2 (Roche Diagnostics). The SARS-CoV-2 antibody showed high level of total SARS-CoV-2 antibodies, with the Cut off Indexes (COI) anti SARS-Cov-2 antibody were still quite high (132 U/mL). The highest donor antibody COI (204.6 U/mL) was seen in 11th donation at 6 months after recovery, while the lowest antibody COI (130.8 U/mL) was in 15th donation at 7 months after recovering. Evaluation of donor health status were performed after the 16th donation and analyzed as well. In conclusion, 16 CCP donations of 600 mL resulting in 48 units of 200 mL plasma in 8 months was safe for the donor, with the SARS-Cov-2 antibody titer remained high in the whole period.

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Journal Info

Abbrev

JKKI

Publisher

Subject

Medicine & Pharmacology Public Health

Description

JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and ...