<![CDATA[Highlights The presence of preoperative Modic changes tends not to affect clinical outcomes after ACDF due to degenerative pathology, including disc herniation. Preoperative Modic changes are correlated with a worse preoperative picture. Abstract Background: Modic Change (MC) is a phenomenon that can be found in Magnetic Resonance Imaging (MRI) of patients with degenerative spinal diseases and in the cervical region. The effect of Modic change on the clinical outcome of postoperative patients has not been fully established. Anterior Cervical Discectomy and Fusion (ACDF) is a procedure that has become the gold standard in treating cervical disc herniation because it is able to eliminate pathological lesions and prevent the recurrence of nerve compression. Objective: This study aimed to determine the effect of MC on the clinical outcome of patients undergoing ACDF therapy due to degenerative disc pathology, including cervical disc herniation. Material and Method: This was a systematic review using filtered literature based on PICOs. The variables examined in this study were "modic change", "ACDF", and "clinical outcome". Data were collected from three databases, which were then screened based on eligibility criteria, assessed for study quality, and reviewed using a qualitative descriptive method. Result: A total of six articles published between 2017 and 2021 were included in this study. This study was an observational study with a retrospective cohort method. Preoperative Modic changes tend not to affect clinical outcomes after ACDF. Conclusion: The presence of preoperative Modic changes tends not to affect clinical outcomes after ACDF due to degenerative disc pathology, including disc herniation, but remains a risk factor for postoperative disability and provides a worse preoperative picture.]]>
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