Studi Bioekivalensi Obat Paracetamol Generik Dan Non Generik Secara In Vitro

Siti Mutaharah (Universitas Sari Mulia)
Saftia Aryzki (Universitas Sari Mulia)
Rina Saputri (Universitas Sari Mulia)
Yusuf Anggoro Mukti (Universitas Sari Mulia)

Sains Medisina
Vol 1 No 6 (2023): Sains Medisina

Drugs are one component of health that is irreplaceable in order to improve public health status. There are 2 types of drugs circulating in the market, namely generic and non-generic. Paracetamol is classified as a class 1 biopharamcetic drug which is formulated as a product with high solubility in water and has high intestinal permeability, almost 100% absorption can be expected at least as much as 85% of the soluble product in in vitro testing. In vitro testing was carried out for 180 minutes with a span of 15 minutes using generic paracetamol and patented paracetamol to determine whether there is a difference in the quality of the drugs and to make comparisons with the aim of knowing their bioequivalence.