<![CDATA[Diuretics are substances that can increase the rate of excretion of urine volume and indicate the amount of expenditure (loss) of solutes and water. The Alang-Alang rhizome and the Cat's Whiskers plant are one of the many plants that have many advantages and have been used for a long time in an effort to maintain health. This study aims to determine the combined activity of Alang-alang (Imperata cylindrical L.) Rhizome Extract and Kumis Leaf Extract. Cat (Orthosiphon stamineus L.) as a diuretic in mice (Mus musculus). The test animals were divided into 5 groups, each group consisted of 3 test animals. Group I was given a 1% w/v Na-CMC colloidal solution as a control. Groups II, III and IV were given a suspension of a combination of Alang-Alang rhizome extract and Kumis Kucing Leaf extract with each dose of 100 mg/Kg BW ratio (1 : 1), (1 : 2) and (2 : 1) as the treatment group. The highest to lowest diuretic activity sequentially with the average value being furosemide (3.67), combination (Alang-Alang rhizome: Daun Kumis Kucing) 2 : 1 (2.67), combination (Rimpang Alang-Alang: Daun Kumis Kucing) ) 1 : 2 (1,33), and a combination (Alang-Alang Rhizome: Cat's Whisker Leaf) 1 : 1 (1,33). The largest combination dose that gave an increase in urinary frequency was at a combination dose of 2: 1 (Rhimpang Alang-Alang: Daun Kumis Kucing) with an average value of 2.67.]]>
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