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Edi Kamal, Sainal
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Antipyretic Effectiveness Test from Dragon (Pyrosia piloselloides) (L) M. G. Price) Leaves Extract in Male Marmutes (Cavia Procellus) Edi Kamal, Sainal; Prayitno, Suprapto; Hamdi, Syaibatul
Jurnal Farmasi Sandi Karsa Vol 7 No 1 (2021): Jurnal Farmasi Sandi Karsa (JFS)
Publisher : Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36060/jfs.v7i1.77

Abstract

This study aims to determine Effectiveness Of Dragon Scale Leaves (Pyrrosia piloselloides (L.) M. G. Price) As An Antipyretic In Male Marmut (Cavia porcellus) induced with 5% peptone. This study used 15 male guinea pigs which were divided into V groups. roup I was given negative control (Na. CMC 1% w/v), groups II, III and IV were given dragon scales leaf extract at a dose of 250 mg/kg, 500 mg/kg, and 750 mg/kg and group V was given a positive control. (Paracetamol). previously induced with 5% peptone subcutan. measurements of body temperature rectally were carried out every 30 minutes, survived 4 hours. The results showed that the administration of dragon scales leaf extract at a dose of 250 mg/kg, 500 mg/kg, and 750 mg/kg of body weight gave an antipyretic effect against male guinea pigs and the most optimal effect is obtained at a dose of 750 mg/kgBW which is 129,05% compared to paracetamol which is 146,19%.
Diuresis Activity of A Combination of Alang-Alang Rhyme Extract (Imperata cylindrical L.) and Cat's Whistle Leaves (Orthosiphon stamineus L.) in Male Mice (Mus musculus). Edi Kamal, Sainal; Yusti, Yusti
Jurnal Farmasi Sandi Karsa Vol 8 No 1 (2022): Jurnal Farmasi Sandi Karsa (JFS)
Publisher : Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36060/jfs.v8i1.100

Abstract

Diuretics are substances that can increase the rate of excretion of urine volume and indicate the amount of expenditure (loss) of solutes and water. The Alang-Alang rhizome and the Cat's Whiskers plant are one of the many plants that have many advantages and have been used for a long time in an effort to maintain health. This study aims to determine the combined activity of Alang-alang (Imperata cylindrical L.) Rhizome Extract and Kumis Leaf Extract. Cat (Orthosiphon stamineus L.) as a diuretic in mice (Mus musculus). The test animals were divided into 5 groups, each group consisted of 3 test animals. Group I was given a 1% w/v Na-CMC colloidal solution as a control. Groups II, III and IV were given a suspension of a combination of Alang-Alang rhizome extract and Kumis Kucing Leaf extract with each dose of 100 mg/Kg BW ratio (1 : 1), (1 : 2) and (2 : 1) as the treatment group. The highest to lowest diuretic activity sequentially with the average value being furosemide (3.67), combination (Alang-Alang rhizome: Daun Kumis Kucing) 2 : 1 (2.67), combination (Rimpang Alang-Alang: Daun Kumis Kucing) ) 1 : 2 (1,33), and a combination (Alang-Alang Rhizome: Cat's Whisker Leaf) 1 : 1 (1,33). The largest combination dose that gave an increase in urinary frequency was at a combination dose of 2: 1 (Rhimpang Alang-Alang: Daun Kumis Kucing) with an average value of 2.67.
Ethnopharmacy Study on the Use of Medicinal Plants in Lakawali Village, Malili District, East Luwu District (Padoe Tribes and Other Immigrant Tribes) Edi Kamal, Sainal; Kadang, Yuniharce; Ananda, Febria
Jurnal Farmasi Sandi Karsa Vol 8 No 1 (2022): Jurnal Farmasi Sandi Karsa (JFS)
Publisher : Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36060/jfs.v8i1.106

Abstract

Ethnopharmacy is a combination of disciplines that study the relationship between cultural habits in a community group in terms of its pharmaceutical side. This study aims to obtain information about the ethnopharmaceutical use of medicinal plants based on the types of medicinal plants part of the plant, the benefits of plants, processing methods and the use of medicinal plants used by the people of Lakawali Village, Malili District, East Luwu Regency. This type of research is descriptive observation. The sampling in this study used primary data obtained through interviews with 60 family heads of the people of Lakawli Village, Malili District, East Luwu Regency. The results of this study indicate that there are 33 types of medicinal plants divided into 26 families with 20 types of diseases. The most widely used plant as a medicine is Tappa Lorong/Brotowali which is efficacious as an ulcer medicine. Parts of plants used as medicine by the community include leaves, stems, fruits, flowers, bark, fruit skins, rhizomes, seeds, tubers. The most widely used plant part as medicine is the leaf with a percentage of 46%. The processing method and the use of medicinal plants by the community in Lakawali Village, Malili District, East Luwu Regency, are processed by boiling, pounding, squeezing, burning, and grating. And as for how to use it, namely by drinking, eating, making juice and affixed to the sick part.
Pancreas Protective Effects of Telang Flower Extract (Clitoria ternatea L.) Against induced Male White Rats (Rattus norvegicus) Aloksan Edi Kamal, Sainal; Rusli, Rusli; Fani Temarwut, Farid; Biana Sary, Skolastika
Jurnal Farmasi Sandi Karsa Vol 8 No 2 (2022): Jurnal Farmasi Sandi Karsa (JFS)
Publisher : Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36060/jfs.v8i2.115

Abstract

Studies have been conducted on the protective effects of pancreatic telang flower extract (Clitoria ternatea L.) against white rats (Rattus norvegicus) induced by alloxane-induced by laboratory experiential methods. Thegoal is to determine the protective effect of pancreatic telang flower extract (Clitoria ternatea L.) against white rats (Rattus norvegicus) induced by alloxane which has the potential to be anti-diabetic. The mice used were 15 heads, the mice were divided into 5 groups. Each group consisted of 3 mice. Three groups were given a suspension of Telang Flower Extract at a dose of 150 mg/kgBB, 300 mg/kgBB, 450 mg/kgBB, and 1 group as a negative control was given a 1% Na-CMC suspension w/v. The administration of telang flower extract was carried out for 5 days and induced by aloksan of 150 mg / KgBB for 2 days. Blood draws are carried out 3 times, namely on the first day, day 6, and day 8 and then measurements of glucose and albumin levels are carried out. Based on the research that has been carried out, it can be concluded that the administration of telang flower extract (Clitoria ternatea L.) at a dose of 150 mg/KgBB,300 mg/KgBB, and 450 mg / KgBB have a protective effect not significantly different.
Potensi Hiperglikemia Kombinasi Ekstrak Kulit Buah Semangka (Citrullus lanatus) Dan Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) Edi Kamal, Sainal; Roosevelt, Alfreds; Patandung, Gerfan; Amiruddin, Achmad
Jurnal Farmasi Sandi Karsa Vol 9 No 2 (2023): Jurnal Farmasi Sandi Karsa (JFS)
Publisher : Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36060/jfs.v9i2.129

Abstract

This study aims to determine the potential hyperglycemia of the combination of Watermelon Skin Extract (Citrullus lanatus) and Red Dragon Fruit Skin Extract (Hylocereus polyrhizus). The research method used is the alloxane induction method. Rats were divided into 5 groups, namely positive control given metformin 45 mg / Kg BB, negative control given Na. CMC 1% w/v, and variations of test groups given combination extracts with concentration variations of 6% and 13.4%; 9% and 16.4%; and 12% and 19.4% then each group was induced alloxane at a dose of 24 mg / 200g BB. The results of the study on the negative control given NaCMC 1% did not show a decrease in blood sugar levels, in the positive control given metformin 45 mg / KgBB showed an average percent decrease of 94.12%, in the combination extract test group with a dose of 6% and 13.4% showed an average percent decrease of 25.04%; 9% and 16.4% % showed an average percent decrease of 24.69%; and 12% and 19.4% % showed an average percent decrease of 55.61%. Based on the results of this study, a combination extract of 12% and 19.4% can reduce blood sugar levels of white rats. This study proved that red watermelon peel extract and red dragon fruit peel extract have antihyperglycemia effects.
Co-Authors Amiruddin, Achmad Ananda, Febria Biana Sary, Skolastika Fani Temarwut, Farid Hamdi, Syaibatul Kadang, Yuniharce Patandung, Gerfan Prayitno, Suprapto R. Rusli Roosevelt, Alfreds Yusti Yusti, Yusti