The learning process of biology hasn’t led to direct observation of the object to be studied, this has an impact on the development of students' science process skills which cannot be oriented properly to the learning process of biology. The purpose of this study was to determine the application of the android version of RPG Maker MV based learning games to improve science process skills on the concept of viruses. The research method used Quasi-Experimental Design with Nonequivalent Control Group Pretest-Postest. The results showed the value of Sig. (2-tailed) of 0.000 <0.05, student responses> 50%, the rest answered strongly agree. So it can be concluded that, there is a significant difference in effectiveness between the implementation of the android version of the RPG Maker MV based learning game "Felix And The Virology Zone" with conventional methods in improving science process skills and students give very positive responses.
                        
                        
                        
                        
                            
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