Contemporary Journal of Applied Sciences (CJAS)
Vol. 1 No. 1 (2023): November 2023

Prediction of Pinostrobin Pharmacokinetics from Temu Kunci (Boesenbergia rotunda (L.) Mansf.) Using pkCSM

Faisal Akhmal Muslikh (Institut Ilmu Kesehatan Bhakti Wiyata)
Anis Akhwan Dhafin (Universitas Kadiri)
Fendy Prasetyawan (Universitas Kadiri)



Article Info

Publish Date
30 Nov 2023

Abstract

Indonesia is a megabiodiversity country with the second-largest abundance of biodiversity in the world. Temu kunci (Boesenbergia rotunda (L.)) is a well-known traditional medicinal plant in Indonesia with many nutritional and therapeutic benefits. It is known to have good pharmacological activity, which is due to the content of secondary metabolites commonly known as pinostrobin. However, more scientific data is still needed to justify its increased use, especially regarding its pharmacokinetics and safety. The aim of the research was to predict the pharmacokinetic properties of pinostrobin compounds. The pinostrobin compound was obtained from PubChem, accessible at https://pubchem.ncbi.nlm.nih.gov/, and then pharmacokinetic analysis was carried out using a web tool (https://biosig.lab.uq.edu.au/pkcsm/prediction). The research results show that the pinostrobin compound is a compound that has pharmacokinetic properties, showing that this compound has poor distribution and toxicity capabilities.

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Journal Info

Abbrev

cjas

Publisher

Subject

Religion Computer Science & IT Decision Sciences, Operations Research & Management Education Social Sciences

Description

Contemporary Journal of Applied Sciences (CJAS) is a peer-reviewed journal of applied sciences publishing in both English and Indonesian. CJAS Journal aims to provide an platform for disseminating applied sciences, it features articles and reviews by experts, and invites contributions from all areas ...