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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Inovasi Farmasi Indonesia Jurnal Mandala Pengabdian Masyarakat Well Being Journal Of Human And Education (JAHE) Jurnal Ilmiah STIKES Yarsi Mataram Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Contemporary Journal of Applied Sciences (CJAS) International Journal of Global Sustainable Research Gotong Royong Jurnal Pengabdian Kepada Masyarakat Al-Amin International Journal of Contemporary Sciences (IJCS) Journal of Community Engagement in Health
Anis Akhwan Dhafin
Program Studi S1 Farmasi, Fakultas Ilmu Kesehatan, Universitas Kadiri, Indonesia
Religion Humanities Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Prediction of Pinostrobin Pharmacokinetics from Temu Kunci (Boesenbergia rotunda (L.) Mansf.) Using pkCSM Faisal Akhmal Muslikh; Anis Akhwan Dhafin; Fendy Prasetyawan
Contemporary Journal of Applied Sciences Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/cjas.v1i1.6977

Abstract

Indonesia is a megabiodiversity country with the second-largest abundance of biodiversity in the world. Temu kunci (Boesenbergia rotunda (L.)) is a well-known traditional medicinal plant in Indonesia with many nutritional and therapeutic benefits. It is known to have good pharmacological activity, which is due to the content of secondary metabolites commonly known as pinostrobin. However, more scientific data is still needed to justify its increased use, especially regarding its pharmacokinetics and safety. The aim of the research was to predict the pharmacokinetic properties of pinostrobin compounds. The pinostrobin compound was obtained from PubChem, accessible at https://pubchem.ncbi.nlm.nih.gov/, and then pharmacokinetic analysis was carried out using a web tool (https://biosig.lab.uq.edu.au/pkcsm/prediction). The research results show that the pinostrobin compound is a compound that has pharmacokinetic properties, showing that this compound has poor distribution and toxicity capabilities.
The Efficacy of Antiviral Medications in Managing Blood Oxygen Levels in Covid-19 Patients Afflicted by Chronic Kidney Conditions Fendy Prasetyawan; Faisal Akhmal Muslikh; Anis Akhwan Dhafin; Elsa Mahardika Putri; Yuneka Saristiana; Susilo Margining Raharjo
Contemporary Journal of Applied Sciences Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/cjas.v1i1.7030

Abstract

This research assesses the efficacy and safety of employing antiviral drugs in individuals with COVID-19 and chronic kidney disease. The study results reveal a reduced effectiveness of the drug in enhancing oxygen saturation in patients, as indicated by a p-value of 0.026 for SpO2. Consequently, the administration of antiviral drugs to individuals with chronic kidney disease warrants careful consideration. Moreover, there is a need to pay attention to the safety aspects of antiviral drug utilization, particularly with a p-value of 0.026 for Clcr. It is advisable to refrain from using specific antiviral drugs, such as favipiravir, in COVID-19 patients with chronic kidney conditions. However, contemplating the use of remdesivir at an appropriate dosage may be viable if the patient's glomerular filtration rate (GFR) exceeds 30 ml/minute. The study's conclusion underscores the significance of meticulous and personalized management when employing antiviral drugs in COVID-19 patients with chronic kidney disease. A comprehensive consideration of factors such as effectiveness, safety, and the patient's renal health is imperative to ensure an optimal and tailored treatment approach.
Total Plate Count Test for Bacteria in Home industry Baby Porridge in the Malang City Area Anis Akhwan Dhafin; Elsa Mahardika Dhafin; Faisal Akhmal Muslikh; Fendy Prasetyawan
Contemporary Journal of Applied Sciences Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/cjas.v1i1.7036

Abstract

The growth and development of toddlers greatly influences the quality of human resources in the future so that the toddler years are an important period in human development. In nutritional development, food has an important role in growth. During the toddler years, apart from breast milk, babies also need additional food, namely MP-ASI. MP-ASI can be contaminated by chemical and biological contaminants, one of the biological contaminants in food is bacteria. The TPC (Total Plate Count) test is a test used to count the number of bacterial colonies in the media being tested. The stages carried out before testing are sample dilution and media formulation. This research aims to determine whether or not there are bacteria in samples of Home industry Baby Porridge sold in the city of Malang. The samples studied were 8 samples. The sampling technique was carried out by purposive sampling. Based on the research that has been carried out, it can be concluded that of the 8 samples of home industry baby porridge sold in the city of Malang, 2 samples meet the requirements with the condition that the number of colonies is 2 x 10 2 colonies/g. The remaining 6 samples did not meet the requirements.
Efficacy of Antiviral Medications in Decreasing Inflammation Levels Among Covid-19 Patients Experiencing Chronic Kidney Disease (CKD) Fendy Prasetyawan; Faisal Akhmal Muslikh; Anis Akhwan Dhafin; Elsa Mahardika Putri; Yuneka Saristiana; Susilo Margining Raharjo
Contemporary Journal of Applied Sciences Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/cjas.v1i1.7037

Abstract

Individuals with Chronic Kidney Disease (CKD) face an elevated risk of severe COVID-19 infection. A comprehensive investigation into the effectiveness of antiviral medications in treating COVID-19 patients is imperative. The primary goal is to assess the severity of the illness and the efficacy of antiviral drugs in individuals with COVID-19 and CKD following antiviral treatment at Dr. Soedomo Trenggalek Hospital. This study adopts a cross-sectional approach, employing purposive sampling for sample selection. Retrospective data from 2022 medical records of COVID-19 patients diagnosed with CKD are analyzed. The research findings highlight the efficacy of antiviral drugs in diminishing inflammation levels in COVID-19 patients, as indicated by a significant p-value of 0.000. However, the leukocyte data proved inadequate in determining the reduction in inflammatory levels. Therefore, obtaining data on C-reactive protein (CVR) and lymphocytes is crucial for a more accurate measurement. The p-value for ClCr is 0.842.
Analysis of Compliance Levels and Quality of Life Perspectives for Outpatient Hypertension Patients at Hospital X, Mojokerto Regency Anis Akhwan Dhafin; Fendy Prasetyawan; Elsa Mahardika Putri; Muhammad Alviyan Shutiawan; Okky Intan Mawarni; Faisal Akhmal Muslikh
International Journal of Global Sustainable Research Vol. 1 No. 3 (2023): November 2023
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59890/ijgsr.v1i3.829

Abstract

The incidence of hypertension in the world in 2021 is estimated at 1.28 billion adults worldwide suffering from hypertension and 3 million of them die every year. Seven out of ten sufferers do not receive treatment. Hypertension sufferers in East Java in 2021 aged over 15 years are estimated to be 11,686,430, with a total of 48.38% men and 51.62% women. Of this number, 9.70% of hypertension sufferers received treatment. Low compliance with taking medication causes hypertension to get worse and will affect the quality of life of someone suffering from hypertension. This research is a prospective quantitative research using a cross sectional research design. Using a side sampling technique. The number of samples in the study was 100 patients. The results of this study showed that the highest level of medication adherence was in the medium category at 61%, high 31% and low 9%. The level of quality of life for hypertensive patients in the moderate category is 56%, low 35% and high 9%.
Evaluation of Medication Errors in Prescriptions Pediatric Patients Are Reviewed from the Prescribing Phase Elsa Mahardika Putri; Fendy Prasetyawan; Anis Akhwan Dhafin
International Journal of Global Sustainable Research Vol. 1 No. 3 (2023): November 2023
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59890/ijgsr.v1i3.844

Abstract

Medication error is an error in the administration of drugs or the use drugs that endangers patients and is carried out by health workers, especially in terms of patient treatment services that can actually be prevented. The purpose of this study was to determine the percentage incidence of medication errors in the prescribing phases in the prescription of concoctions of pediactric patients. This study is a non-experimental study with an observational descriptive research design and the collection of prescription data using purposive sampling technique. The result of the research that has been carried out, the incidence of medication errors that most occur in the Sukorame Health Center Pharmacy Installation is in prescribing phase at 93%.
Physicochemical and Pharmacokinetic Property Prediction of Substances in Centella asiatica using pkCSM: Prospects for the Creation of Therapeutic Formulations from Plant Isolates Faisal Akhmal Muslikh; Fendy Prasetyawan; Rosa Juwita Hesturini; Fita Sari; Anis Akhwan Dhafin; Muhammad Alviyan Shutiawan; Elsa Mahardika Putri; Okky Intan Mawarni
International Journal of Global Sustainable Research Vol. 1 No. 3 (2023): November 2023
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59890/ijgsr.v1i3.892

Abstract

Indonesia is a megabiodiversity country with the second-largest abundance of biodiversity in the world. Centella asiatica (CA) is an important medicinal herb used in various countries in the world. It is known to have good pharmacological activity, but more scientific data is still needed to justify its increasing use, especially regarding its pharmacokinetics and safety. The aim of the research was to predict the physicochemical and pharmacokinetic properties of the compounds contained in CA. The compound content was obtained from journal references that collected information from Dr. Duke's Phytochemical and Ethnobotanical Database, then each compound was subjected to physicochemical and pharmacokinetic analysis using a web tool. The results show that the compounds quercetin and kaempferol are compounds that have good physicochemical and pharmacokinetic properties compared to other compounds contained in CA.
Strategi Pencegahan COVID-19: Peningkatan Imunitas Tubuh Melalui Edukasi Konsumsi Teh Kombucha Faisal Akhmal; Fendy Prasetyawan; Yuneka Saristiana; Ratna Mildawati; Anis Akhwan Dhafin
Jurnal Pengabdian Al-Amin Vol. 2 No. 1 (2024): January 2024
Publisher : STAI Al-Amin Gersik Kediri Lombok Barat-NTB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54723/jpa.v2i1.138

Abstract

The COVID-19 pandemic, triggered by the coronavirus 2 (SARS-CoV-2), demands a rapid and effective response to protect the global community. This article discusses prevention strategies with a focus on boosting the body's immunity through education and the consumption of kombucha tea. COVID-19 varies in symptoms and impacts, requiring a holistic approach. Kombucha tea, a result of fermenting sweet tea with a SCOBY, provides high nutrition and health benefits, particularly in strengthening the immune system. Community outreach activities are conducted to disseminate information to healthcare professionals and students, discussing the benefits of kombucha tea in enhancing immunity during the pandemic. The methods of these activities involve preparation, implementation of educational sessions, and participant satisfaction evaluations. Research findings highlight the potential of kombucha tea, especially its antioxidant and anti-inflammatory compounds, in enhancing the body's resilience against SARS-CoV-2. This strategy can be reinforced by emphasizing overall healthy lifestyles. Despite its promise, challenges in implementation require effective education and cross-sector collaboration. The conclusion emphasizes the importance of a holistic approach and education in building the foundation of public health amid the pandemic.
Analysis of Beer's Criteria 2019 and Patient Characteristics of Potentially Inappropriate Medication in Elderly Patients with Diabetes Mellitus Anis Akhwan Dhafin; Elsa Mahardika Putri
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.88018

Abstract

Background: Elderly patients with type 2 diabetes mellitus with polypharmacy and various comorbidities often have problems with Potentially Inappropriate Medications (PIMs). One of the methods commonly used to detect this event is Beer's Criteria 2019.Objectives: This study aims to: (1) identify the characteristics of elderly hospitalized patients with type 2 DM; (2) analyze the incidence of PIM in patients; and (3) analyze the relationship between characteristics (age, gender, comorbidities, length of stay, and number of drugs given) with the incidence of PIMs.Methods: The research was conducted at two type C hospitals in the city of Bengkulu, with a total of 105 patients using the purposive sampling method. This research is a cross-sectional study with data collection techniques in the form of medical record data from patients for the period January – December 2022 who received drug therapy. Data analysis consists of comparing data with Beer'’s Criteria, quantitative descriptive and Fisher'’s test.Results: The research results showed that: (1) the largest age group in Hospitals ) had comorbidities, the highest number of drugs given was more than 10 types of drugs, and the majority of patients were hospitalized for less than five days; (2) There was an incidence of PIMs of 98.65% (73 patients) in Hospital (3) Statistical tests show that there is no relationship between age, gender, comorbidities, number of medications and length of stay with the incidence of PIMs.Conclusion: There is still inappropriate use of drugs given to elderly DM patients. It is hoped that further researchers will be able to find out the reasons for giving these drugs to elderly patients.
Gambaran Karakteristik Pasien Lansia Dengan Hipertensi dai Salah Satu Rumah Sakit Kota Bengkulu Tahun 2023: Characteristics Overview of Elderly Patients with Hypertension in One of The Hospitals In Bengkulu City In 2023 Dhafin, Anis Akhwan; Putri, Elsa Mahardika; Mawarni , Okky Intan; Kusumawati, Leny Witaning
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 5 No. 2 (2024): Volume 5 Nomor 2 Juni 2024
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Populasi pada lansia tiap tahunnya meningkat, lansia merupakan kelompok yang memiliki rentan terhadap penyakit. Penyakit yang paling banyak dialami lansia salah satunya hipertensi. Hipertensi ialah peningkatan tekanan darah sistolik >140 mmHg atau tekanan diastolik >90 mmHg. Penyakit Hipertensi merupakan suatu penyakit yang perlu dikhawatirkan, karena tidak ditemukan adanya tanda dan gejala khusus pada penyakit tersebut, hal ini menyebabkan hipertensi sebagai Silent Killer. Tujuan penelitian ini yaitu untuk mengetahui gambaran karakteristik pasien lansia dengan hipertensi di salah satu rumah sakit kota bengkulu tahun 2023. Metode: Penelitian ini menggunakan desain penelitian deskriptif dengan mengambil data sekunder yaitu rekam medis, dan menggunakan perhitungan sampel yaitu total sampling. Hasil: Ditemukan 74 pasien lansia dengan hipertensi yang melakukan pengobatan disalah satu rumah sakit kota bengkulu, mayoritas paling banyak ada di kelompok usia 60-69 tahun dengan jenis kelamin perempuan dan mengalami hipertensi tingkat 2 terbanyak. Sebanyak 65 pasien memiliki penyakit penyerta yang di alami oleh pasien lansia hipertensi ini.
Co-Authors Abd Rofiq Achmad Wahdi Adiyansyah Lukman Hakim Burhan Ma'arif Candra Arifin Charliandri Saputra Wahab Datin An-Nisa Sukmawati Elsa Mahardika Dhafin Elsa Mahardika Putri Elsa Mahardika Putri Elsa Mahardika Putri Elsa Mahardika Putri Faisal Akhmal Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Fendy Prasetyawan Fita Sari Herman Hidayati, Evi Nurul Intan Mawarni, Okky Kurniawati, Evi Kusumawati, Leny Witaning Lukitasari, Dhunik M. Wahyu Ariawan Maharani Dwi Pritiwi Mawarni , Okky Intan Mawarni, Okky Intan Mildawati, Ratna Muhammad Alviyan Shutiawan Muhammad Alviyan Shutiawan Mujtahid Bin Abd Khadir Nanda Ardianto Neni Probosiwi Novyananda Salmasfattah Nur Fahma Laili Okki Intan Mawarni Okky Intan Mawarni Pertiwi, Maharani Dwi Prayoga Feri Yuniarto Prayoga Fery Yuniarto Putri , Elsa Mahardika Putri, Elsa Mahardika Ratna Mildawati Ratna Mildawati Ratna Mildawati Rosa Juwita Hesturini Setyawan, Ferdinta Daniasta Sugeng Rianto Sugeng, Santoso Susilo Margining Raharjo Syendriva Zeptyan Zenmas Tsamrotul Ilmi Winartiana Winartiana, Winartiana Yuneka Saristiana