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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Inovasi Farmasi Indonesia Jurnal Mandala Pengabdian Masyarakat Jurnal Kesehatan Tambusai Well Being Journal Of Human And Education (JAHE) Jurnal Ilmiah STIKES Yarsi Mataram Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Contemporary Journal of Applied Sciences (CJAS) International Journal of Global Sustainable Research Bencoolen Journal of Pharmacy Gotong Royong International Journal of Contemporary Sciences (IJCS) Journal of Community Engagement in Health
Anis Akhwan Dhafin
Program Studi S1 Farmasi, Fakultas Ilmu Kesehatan, Universitas Kadiri, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Prediction of Pinostrobin Pharmacokinetics from Temu Kunci (Boesenbergia rotunda (L.) Mansf.) Using pkCSM Faisal Akhmal Muslikh; Anis Akhwan Dhafin; Fendy Prasetyawan
Contemporary Journal of Applied Sciences Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/cjas.v1i1.6977

Abstract

Indonesia is a megabiodiversity country with the second-largest abundance of biodiversity in the world. Temu kunci (Boesenbergia rotunda (L.)) is a well-known traditional medicinal plant in Indonesia with many nutritional and therapeutic benefits. It is known to have good pharmacological activity, which is due to the content of secondary metabolites commonly known as pinostrobin. However, more scientific data is still needed to justify its increased use, especially regarding its pharmacokinetics and safety. The aim of the research was to predict the pharmacokinetic properties of pinostrobin compounds. The pinostrobin compound was obtained from PubChem, accessible at https://pubchem.ncbi.nlm.nih.gov/, and then pharmacokinetic analysis was carried out using a web tool (https://biosig.lab.uq.edu.au/pkcsm/prediction). The research results show that the pinostrobin compound is a compound that has pharmacokinetic properties, showing that this compound has poor distribution and toxicity capabilities.
The Efficacy of Antiviral Medications in Managing Blood Oxygen Levels in Covid-19 Patients Afflicted by Chronic Kidney Conditions Fendy Prasetyawan; Faisal Akhmal Muslikh; Anis Akhwan Dhafin; Elsa Mahardika Putri; Yuneka Saristiana; Susilo Margining Raharjo
Contemporary Journal of Applied Sciences Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/cjas.v1i1.7030

Abstract

This research assesses the efficacy and safety of employing antiviral drugs in individuals with COVID-19 and chronic kidney disease. The study results reveal a reduced effectiveness of the drug in enhancing oxygen saturation in patients, as indicated by a p-value of 0.026 for SpO2. Consequently, the administration of antiviral drugs to individuals with chronic kidney disease warrants careful consideration. Moreover, there is a need to pay attention to the safety aspects of antiviral drug utilization, particularly with a p-value of 0.026 for Clcr. It is advisable to refrain from using specific antiviral drugs, such as favipiravir, in COVID-19 patients with chronic kidney conditions. However, contemplating the use of remdesivir at an appropriate dosage may be viable if the patient's glomerular filtration rate (GFR) exceeds 30 ml/minute. The study's conclusion underscores the significance of meticulous and personalized management when employing antiviral drugs in COVID-19 patients with chronic kidney disease. A comprehensive consideration of factors such as effectiveness, safety, and the patient's renal health is imperative to ensure an optimal and tailored treatment approach.
Total Plate Count Test for Bacteria in Home industry Baby Porridge in the Malang City Area Anis Akhwan Dhafin; Elsa Mahardika Dhafin; Faisal Akhmal Muslikh; Fendy Prasetyawan
Contemporary Journal of Applied Sciences Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/cjas.v1i1.7036

Abstract

The growth and development of toddlers greatly influences the quality of human resources in the future so that the toddler years are an important period in human development. In nutritional development, food has an important role in growth. During the toddler years, apart from breast milk, babies also need additional food, namely MP-ASI. MP-ASI can be contaminated by chemical and biological contaminants, one of the biological contaminants in food is bacteria. The TPC (Total Plate Count) test is a test used to count the number of bacterial colonies in the media being tested. The stages carried out before testing are sample dilution and media formulation. This research aims to determine whether or not there are bacteria in samples of Home industry Baby Porridge sold in the city of Malang. The samples studied were 8 samples. The sampling technique was carried out by purposive sampling. Based on the research that has been carried out, it can be concluded that of the 8 samples of home industry baby porridge sold in the city of Malang, 2 samples meet the requirements with the condition that the number of colonies is 2 x 10 2 colonies/g. The remaining 6 samples did not meet the requirements.
Efficacy of Antiviral Medications in Decreasing Inflammation Levels Among Covid-19 Patients Experiencing Chronic Kidney Disease (CKD) Fendy Prasetyawan; Faisal Akhmal Muslikh; Anis Akhwan Dhafin; Elsa Mahardika Putri; Yuneka Saristiana; Susilo Margining Raharjo
Contemporary Journal of Applied Sciences Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/cjas.v1i1.7037

Abstract

Individuals with Chronic Kidney Disease (CKD) face an elevated risk of severe COVID-19 infection. A comprehensive investigation into the effectiveness of antiviral medications in treating COVID-19 patients is imperative. The primary goal is to assess the severity of the illness and the efficacy of antiviral drugs in individuals with COVID-19 and CKD following antiviral treatment at Dr. Soedomo Trenggalek Hospital. This study adopts a cross-sectional approach, employing purposive sampling for sample selection. Retrospective data from 2022 medical records of COVID-19 patients diagnosed with CKD are analyzed. The research findings highlight the efficacy of antiviral drugs in diminishing inflammation levels in COVID-19 patients, as indicated by a significant p-value of 0.000. However, the leukocyte data proved inadequate in determining the reduction in inflammatory levels. Therefore, obtaining data on C-reactive protein (CVR) and lymphocytes is crucial for a more accurate measurement. The p-value for ClCr is 0.842.
Analysis of Compliance Levels and Quality of Life Perspectives for Outpatient Hypertension Patients at Hospital X, Mojokerto Regency Anis Akhwan Dhafin; Fendy Prasetyawan; Elsa Mahardika Putri; Muhammad Alviyan Shutiawan; Okky Intan Mawarni; Faisal Akhmal Muslikh
International Journal of Global Sustainable Research Vol. 1 No. 3 (2023): November 2023
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59890/ijgsr.v1i3.829

Abstract

The incidence of hypertension in the world in 2021 is estimated at 1.28 billion adults worldwide suffering from hypertension and 3 million of them die every year. Seven out of ten sufferers do not receive treatment. Hypertension sufferers in East Java in 2021 aged over 15 years are estimated to be 11,686,430, with a total of 48.38% men and 51.62% women. Of this number, 9.70% of hypertension sufferers received treatment. Low compliance with taking medication causes hypertension to get worse and will affect the quality of life of someone suffering from hypertension. This research is a prospective quantitative research using a cross sectional research design. Using a side sampling technique. The number of samples in the study was 100 patients. The results of this study showed that the highest level of medication adherence was in the medium category at 61%, high 31% and low 9%. The level of quality of life for hypertensive patients in the moderate category is 56%, low 35% and high 9%.
Evaluation of Medication Errors in Prescriptions Pediatric Patients Are Reviewed from the Prescribing Phase Elsa Mahardika Putri; Fendy Prasetyawan; Anis Akhwan Dhafin
International Journal of Global Sustainable Research Vol. 1 No. 3 (2023): November 2023
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59890/ijgsr.v1i3.844

Abstract

Medication error is an error in the administration of drugs or the use drugs that endangers patients and is carried out by health workers, especially in terms of patient treatment services that can actually be prevented. The purpose of this study was to determine the percentage incidence of medication errors in the prescribing phases in the prescription of concoctions of pediactric patients. This study is a non-experimental study with an observational descriptive research design and the collection of prescription data using purposive sampling technique. The result of the research that has been carried out, the incidence of medication errors that most occur in the Sukorame Health Center Pharmacy Installation is in prescribing phase at 93%.
Physicochemical and Pharmacokinetic Property Prediction of Substances in Centella asiatica using pkCSM: Prospects for the Creation of Therapeutic Formulations from Plant Isolates Faisal Akhmal Muslikh; Fendy Prasetyawan; Rosa Juwita Hesturini; Fita Sari; Anis Akhwan Dhafin; Muhammad Alviyan Shutiawan; Elsa Mahardika Putri; Okky Intan Mawarni
International Journal of Global Sustainable Research Vol. 1 No. 3 (2023): November 2023
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59890/ijgsr.v1i3.892

Abstract

Indonesia is a megabiodiversity country with the second-largest abundance of biodiversity in the world. Centella asiatica (CA) is an important medicinal herb used in various countries in the world. It is known to have good pharmacological activity, but more scientific data is still needed to justify its increasing use, especially regarding its pharmacokinetics and safety. The aim of the research was to predict the physicochemical and pharmacokinetic properties of the compounds contained in CA. The compound content was obtained from journal references that collected information from Dr. Duke's Phytochemical and Ethnobotanical Database, then each compound was subjected to physicochemical and pharmacokinetic analysis using a web tool. The results show that the compounds quercetin and kaempferol are compounds that have good physicochemical and pharmacokinetic properties compared to other compounds contained in CA.
Gambaran Karakteristik Pasien Lansia Dengan Hipertensi dai Salah Satu Rumah Sakit Kota Bengkulu Tahun 2023: Characteristics Overview of Elderly Patients with Hypertension in One of The Hospitals In Bengkulu City In 2023 Dhafin, Anis Akhwan; Putri, Elsa Mahardika; Mawarni , Okky Intan; Kusumawati, Leny Witaning
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 5 No. 2 (2024): Volume 5 Nomor 2 Juni 2024
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Populasi pada lansia tiap tahunnya meningkat, lansia merupakan kelompok yang memiliki rentan terhadap penyakit. Penyakit yang paling banyak dialami lansia salah satunya hipertensi. Hipertensi ialah peningkatan tekanan darah sistolik >140 mmHg atau tekanan diastolik >90 mmHg. Penyakit Hipertensi merupakan suatu penyakit yang perlu dikhawatirkan, karena tidak ditemukan adanya tanda dan gejala khusus pada penyakit tersebut, hal ini menyebabkan hipertensi sebagai Silent Killer. Tujuan penelitian ini yaitu untuk mengetahui gambaran karakteristik pasien lansia dengan hipertensi di salah satu rumah sakit kota bengkulu tahun 2023. Metode: Penelitian ini menggunakan desain penelitian deskriptif dengan mengambil data sekunder yaitu rekam medis, dan menggunakan perhitungan sampel yaitu total sampling. Hasil: Ditemukan 74 pasien lansia dengan hipertensi yang melakukan pengobatan disalah satu rumah sakit kota bengkulu, mayoritas paling banyak ada di kelompok usia 60-69 tahun dengan jenis kelamin perempuan dan mengalami hipertensi tingkat 2 terbanyak. Sebanyak 65 pasien memiliki penyakit penyerta yang di alami oleh pasien lansia hipertensi ini.
Asistensi Penyusunan Naskah Proposal Penelitian Dan Pengabdian Masyarakat Dengan Metode Lgd (Leaderless Group Discussion) Di Universtias Kadiri Prasetyawan, Fendy; Saristiana, Yuneka; Dhafin, Anis Akhwan; Mildawati, Ratna; Muslikh, Faisal Akhmal; Ariawan, Wahyu
Gotong Royong Vol. 1 No. 1 (2024)
Publisher : CV. Akira Java Bulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63935/gr.v1i1.16

Abstract

The assistance program for drafting research and community service proposals using the Leaderless Group Discussion (LGD) method at Universitas Kadiri aims to enhance the capacity of lecturers and students in producing high-quality and relevant proposals. The LGD method allows each participant to actively engage in discussions without a dominant leader, fostering involvement and constructive collaboration. The program includes preparation, workshop implementation, proposal evaluation, and follow-up stages. Results indicate significant improvements in problem formulation clarity, methodological accuracy, and proposal consistency. Additionally, active participant involvement and the development of collaborative skills were achieved, strengthening an inclusive discussion culture within the academic environment. Evaluations show that the LGD method effectively enhances academic and professional quality, despite challenges in ensuring deep understanding of topics and methodologies. With support from the Universitas Kadiri's Center for Educational Development and Quality Assurance (LP3M) team, this program successfully met its objectives and provides a strong foundation for similar future activities. The outcomes of this program are expected to contribute to improving the quality of innovative and impactful research and community service.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN DAN KULIT BATANG GAMAL (GLIRICIDIA SEPIUM (JACQ) WALP) TERHADAP BAKTERI Staphylococus aureus: ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT OF GAMAL LEAVES AND BARK (GLIRICIDIA SEPIUM (JACQ) WALP) AGAINST STAPHYLOCOCCUS AUREUS BACTERIA Herman; Dhafina, Anis Akhwan; Putri, Elsa Mahardika; Setyawan, Ferdinta Daniasta
WELL BEING Vol 9 No 2 (2024): Well Being
Publisher : LPPM STIKes Bahrul Ulum Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51898/wb.v9i2.284

Abstract

Latar Belakang : Daun Gamal (Gliricidia sepium (Jacq) Walp) memiliki khasiat sebagai antibakteri baik pada daun maupun kulit batangnya. Kandungan zat aktif dalam daun gamal adalah flavonoid, alkaloid, dan saponin. Senyawa flavonoid, alkaloid dan saponin juga terdapat pada kulit batang yang memiliki kemampuan untuk menghambat pertumbuhan bakteri. Subjek dan Metode : Metode maserasi digunakan mengekstraksi daun dan kulit batang gamal menggunakan pelarut etanol 96%, selanjutnya hasil ekstraksi dipekatkan menggunaka evaporasi dengan tujuan menhasilkan ekstrak kental. Hasil : Hasil penelitian Ekstrak daun gamal pada bakteri Staphylococus aureus dengan masing-masing konsentrasi 5%, 10%, 20%, dan 40% di dapatkan rata-rata zona hambat 25,0 mm, 28,00  mm, 30,00mm, dan 35,00mm. Kontrol positif dan negatif memiliki rata-rata 42,00mm dan 0,00mm. Ekstrak kulit batang gamal pada bakteri Staphylococus aureus dengan masing-masing konsentrasi 5%, 10%, 20%, dan 40% didapatkan rata-rata zona hambat 25,33 mm, 29,33 mm, 31,33 mm, dan 33,00 mm. Kesimpulan: Berdasarkan hasil penelitian yang telah dilakukan  dapat disimpulkan bahwa: Ekstrak daun dan kulit batang gamal (Gliricidia sepium (Jacq) Walp) memiliki efektiftivitas terhadap pertumbuhan bakteri Staphylococus aureus. Pada konsentrasi 5%, 10%, 20%, dan 40% Ekstrak etanol daun dan kulit batang gamal (Gliricidia sepium Jacq) Walp) memiliki efektiftivitas terhadap bakteri Staphylococus aureus
Co-Authors Achmad Wahdi Adhitama, Laily Vitria Ardianto, Nanda Candra Arifin, Candra Charliandri Saputra Wahab Elsa Mahardika Dhafin Elsa Mahardika Putri Elsa Mahardika Putri Elsa Mahardika Putri Evi Kurniawati, Evi Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Fendy Prasetyawan Fita Sari Hakim, Adiyansyah Lukman Herman Hidayati, Evi Nurul Intan Mawarni, Okky Khadir, Mujtahid Bin Abd Kusumawati, Leny Witaning Laili, Nur Fahma Lukitasari, Dhunik M. Wahyu Ariawan Ma'arif, Burhan Maharani Dwi Pritiwi Mawarni , Okky Intan Mawarni, Okky Intan Mildawati, Ratna Muhammad Alviyan Shutiawan Neni Probosiwi Okki Intan Mawarni Okky Intan Mawarni Pertiwi, Maharani Dwi Pratiwi, Maharani Dwi Putri , Elsa Mahardika Putri, Elsa Mahardika Raharjo, Susilo Margining Rofiq, Abd Rosa Juwita Hesturini Salmasfattah, Novyananda Setyawan, Ferdinta Daniasta Shutiawan, Muhammad Alviyan Sugeng Rianto Sugeng, Santoso Sukmawati, Datin An-Nisa Susilo Margining Raharjo Tsamrotul Ilmi Winartiana Winartiana, Winartiana Wiryani, Luh Santhi Utami Yuneka Saristiana Yuniarto, Prayoga Feri Yuniarto, Prayoga Fery Zenmas, Syendriva Zeptyan