Buschke Lowenstein tumor (BLT)/giant condyloma acuminatum (GCA): An immunopathogenesis insight

Paulus Mario Christopher (Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia)
Hartono Kosim (Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia)
Ratna Sari Wijaya (Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia)
Silvi Suhardi (Department of Dermatovenereology, Universitas Tarumanagara, Indonesia)
Linda Julianti (Department of Dermatovenereology, Universitas Tarumanagara, Indonesia)

Bali Dermatology Venereology and Aesthetic Journal
BDVJ - Vol. 3 No. 1 (June 2020)

Buschke Lowenstein tumor (BLT)/giant condyloma acuminatum is a rare variant of sexually transmitted infection caused by human papillomavirus (HPV) type 6 and 11. HPV has its viral factors that exist to avoid immune surveillance and control through 1) infecting only the basal layer of the epithelium, 2) downregulation of host immunity, 3) suppression of proinflammatory proteins essential for viral clearance. The incidence of BLT/GCA is estimated to be 0.1% in the general population, with males having 2.7 times increased risk than females. The definitive diagnosis of BLT/GCA is typical morphology along with histopathological examination, and/or viral serotyping. Treatment of BLT/GCA requires a multidisciplinary approach, determined based on age, the extent of the lesion, organ involvement, and organ location.