<![CDATA[Neutrophils occur in periodontitis, an infection of the periodontal tissue that may increase the risk of diabetes. Because of its excellent physicochemical properties and biological capabilities, hydrogel is a promising biomaterial for treating periodontal disease. This study consisted of four groups of Acemannan hydrogel 25%, 50%, 75%, and the Federer formula was used to determine the sample size and six replicate experiments were performed for each group to form a positive control group. Considering the investigation's conclusions, in the acemannan hydrogel administration group, the average ± SD levels of neutrophils in samples on day 3 were 25%, 50%, and 75%, and the positive control group was 3.08 ± 0.736. 2.46 ± 0.459; 1.54 ± 0.510; 1.17 ± 0.258. This value decreased to 1.83 ± 0.258 by day 5 were 1.29 ± 0.459; 0.50±0.447; 0.21 ± 0.292. As a result of the Kruskal-Wallis statistical test, there was a significant difference in the average number of neutrophils after administering 25%, 50%, and 75% Acemannan hydrogel and the positive control group to rats with alloxan-induced Wistar periodontitis on the third and fifth days. The study's findings suggest that 75% of acemannan hydrogel is the most effective concentration for reducing neutrophils]]>
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