<![CDATA[Fibrosarcoma is cancer that originates from fibroblast cells that grow uncontrollably and indefinitely. Surgery, chemotherapy, and radiotherapy are commonly used anticancer therapies, but still have a negative effect on normal body cells, so alternative therapies are carried out using replication of oncolytic viruses, namely Newcastle disease virus. The purpose of this study was to determine the damage or negative effects on the spleen organ after virotherapy using Newcastle disease virus by observing the histopathological picture. This study used 12 rats that had been induced benzo(a)pyrene, after macroscopically observed cancer with a diameter of 3-4 mm, 6 tails with almost uniform cancer size. Grouped into two treatments, namely the control group (P0) injected with Phosphate Buffer Saline (PBS) amounting to 0.5 mL and the treatment group (P1) injected with Newcastle disease virus at a dose of 0.5 mL/28 HA units. The variables observed were congestion lesions, hemorrhage, and necrosis. The results of histopathological observations from both groups showed no specific damage to the spleen organ, but lymphocyte proliferation was observed. Based on these results, it can be concluded that virotherapy with Newcastle disease virus isolate Gianyar-1/AK/2014 has no effect on the histopathology of the spleen of white rats with fibrosarcoma.]]>
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