Jurnal Respirasi (JR)
Vol. 10 No. 1 (2024): January 2024

The Role of Genome-Wide Association Study in Pulmonary Disease Diagnostics: A Review in Medical Bioinformatics

Rossalyn Andromeda (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia.)
Irandi Putra Pratomo (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine/Pulmonology and Respiratory Medicine Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia/Bioinformatics Core Facilities, Indonesian Medical Educa)
Ahmad Fauzi (Nursing Unit, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia.)
Tutug Kinasih (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine/Pulmonology and Respiratory Medicine Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia.)
Prasenohadi Prasenohadi (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia/Indonesian Medical Association/Indonesian Society of Respirology, Jakarta, Indonesi)
Arif Santoso (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia/Indonesian Medical Association/Indonesian Society of Respirology, Jakarta, Indonesia.)
Kentaro Tokumo (Department of Clinical Oncology, Hiroshima University Hospital, Hiroshima, Japan.)



Article Info

Publish Date
30 Jan 2024

Abstract

Biomedical science, which initially required only conventional research in the laboratory, currently involves information technology and has created bioinformatics in its development. Bioinformatics, a branch of biology, quantitatively analyzes information within biological macromolecules using software. Contemporary applications of bioinformatics have advanced biotechnological, medical, and pharmaceutical practices. Among the established applications of bioinformatics is diagnosing lung diseases using the genome-wide association study (GWAS) technique. Owing to sequencing technology and rapid computational methods, this technique is applied to analyze the link between genes with essential traits in the population, thus mapping the target genes to diagnose and treat diseases. The lung diseases diagnosed using GWAS include the responsible locus in asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Moreover, it can identify the treatment for COPD and suggest a new locus in lung cancer. Advancing the current gene-mapping technology demands genotype and phenotype data to study disease-linked genomes. Currently, bioinformatics is barely known and receives little attention in Indonesia. However, it can grow rapidly through open-source basis data and cross-disciplinary collaboration.

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Journal Info

Abbrev

JR

Publisher

Subject

Health Professions Medicine & Pharmacology Public Health

Description

Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in ...