Phytochemical Screening and α-glucosidase Inhibitory of Secang Wood (Caesalpinia sappan L.)

Aktsar Roskiana Ahmad (Master of Pharmacy Graduate Program, Universitas Muslim Indonesia, Makassar Bachelor of Pharmacy, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar)
Tiara Katulista Islamia (Master of Pharmacy Graduate Program, Universitas Muslim Indonesia, Makassar Bachelor of Pharmacy, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar)
Asni Amin (Master of Pharmacy Graduate Program, Universitas Muslim Indonesia, Makassar Bachelor of Pharmacy, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar)

Jurnal Fitofarmaka Indonesia
Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)

Secang wood (Caesalpinia sappan L.) is a part of the Secang plant which is widely used to treat various diseases, including diabetes. Based on previous research, secang wood contains flavonoids which have the potential to inhibit the α-glucosidase enzyme. The research aims to determine the potential of ethanol extracted by meseration using 96% ethanol. Inhibition of activity was tested using microplate reader which was measured at a wavelength of 405 nm with acarbose as a comparison. The results of the research show that the ethanol extract of secang wood has inhibitory activity, including it in the active category based on the % inhibition value obtained at 83.63%. Meanwhile, acarbose has inhibitory activity, including it in the very active category with a %inhibition value of 79%.