Three resveratrol’s oligomers from the stem bark of H. gregaria (dipterocarpaceae) and their toxicity and citotoxicity

., Sahidin ( Department of Chemistry, faculty of Mathematics and Natural Science Haluoleo University, Kendari, Southeast Sulawesi, Indonesia Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung)
Hakim, Euis H. ( Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung)
Syah, Yana M. ( Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung)
Juliawaty, Lia D. ( Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung)
Achmad, Sjamsul A. ( Natural Organic Chemistry Research Club, Chemistry Program Institut Teknologi Bandung)
Latip, Jalifah ( School of Chemical Sciences & Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor D.E., Malaysia)

INDONESIAN JOURNAL OF PHARMACY
Vol 17 No 3, 2006

Three resveratrol oligomers have been isolated from the stem bark of H. gregaria including a resveratrol trimer i.e. α-viniferin (1), and two resveratrol tetramers i.e. vaticanol B (2) and hopeaphenol (3). These structures were determined by spectroscopic evidence including UV, IR, 1H , 13C NMR and compared with that of the reported data in the literatures. Activities of the compounds were determined toward brine shrimp Artemia salina (toxicity) and murine leukemia P-388 cells (cytotoxicity). The compound 1 is the most active against A. salina (LC50 = 49,0 ± 5,8 μg/mL), and the compound 3 has very active level toward murine leukemia P-388 cells (LC50 = 5,7 ± 0,3 μM).Key words : Resveratrol oligomers, H. gregaria, toxicity, and cytotoxicity.