Anti-inflammatory activity of dominant compound of mahkota dewa fruit Phaleria macrocarpa Scheff. Boerl

Mariani, Ria (Pharmacy, Faculty of Maths and Science (FMIPA), Universitas Garut, Garut, Indonesia)
Wirasutisna, Komar Ruslan (School of Pharmacy, Institute of Technology Bandung, Indonesia)
Nawawi, As’ari (School of Pharmacy, Institute of Technology Bandung, Indonesia)
Adnyana, I Ketut (School of Pharmacy, Institute of Technology Bandung, Indonesia)

INDONESIAN JOURNAL OF PHARMACY
Vol 21 No 2, 2010

The anti-inflammatory effectof dominant compound of mahkota dewa fruit (Phaleria macrocarpaScheff. Boerl), a hydroxyl benzophenon glucoside,to Wistar  female  rats  (using  λ-karagenan  as  inflammatory  inducer)  has  been investigated.   The inflammation was measured by pletismometer.  The test has been used physiology NaCl solution as a control andNaproxen at a dose of 22.5 mg/kg body weight as a standard. Anti-inflammatorytest was showed that the decreased  inflammation  of  the  isolate  at  a  dose  of  22.5  mg/kg  body  has  twice lower than the standard.Key words:  Phaleria  macrocarpa,  anti-inflammatory  activity,  hydroxyl  benzophenon glucoside