Hepatitis B is a disease caused by infection with the HBV (Hepatitis B Virus) virus that commonly infects the liver and can develop into liver cancer. The disease can be transmitted through blood, semen, breast milk, saliva, vaginal fluids, and sperm. One effective way to prevent Hepatitis B disease is by vaccination. This study will construct a mathematical model, such as the SEITR model, to study the spread of Hepatitis B disease in Ambon City. The SEITR epidemic model is a disease spread model that divides the population into five subpopulation classes, namely the susceptible individual subpopulation class, the exposed individual subpopulation class, the infected individual subpopulation class, the treatment individual subpopulation class, and the recovered individual subpopulation class. Based on the dynamic system analysis conducted, two equilibrium points were obtained, namely the disease-free equilibrium point and the endemic equilibrium point. In addition, based on the data and simulation results, it can be concluded that the spread of Hepatitis B in Ambon City depends on the transmission rate from infected individuals to susceptible individuals
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