Majalah Kedokteran Andalas
Vol 46, No 11 (2024): July 2024

Harnessing the Potential of Synbiotic Therapy for Childhood Malnutrition: A Narrative Review of Onion Inulin Extracts and Probiotic-Rich Dadih

Refa Rahmaddiansyah (Andalas University)
Wahida Rahmi (Andalas University)
Dessy Arisanty (Andalas University)
Rauza Sukma Rita (Andalas University)
Sukarsi Rusti (Universitas Indonesia)



Article Info

Publish Date
28 Oct 2024

Abstract

Malnutrition and undernutrition in children are predominantly attributed to insufficient dietary intake and diseases, posing substantial risks without timely intervention. The emerging field of synbiotics, a symbiotic combination of probiotics and prebiotics, presents a promising avenue in nutritional therapy. It effectively modulates the composition and metabolic activities of the intestinal microbiota. This approach aligns seamlessly with the Sustainable Development Goals for 2030, offering a cost-effective strategy for both prophylaxis and immunomodulation. This study delves into a narrative literature review, examining the potential application of an extract derived from onion (Allium cepa Linn.) inulin, coupled with the beneficial attributes of the probiotic-rich traditional Sumatran dadih, as a supportive therapy. The emphasis lies in manipulating the intestinal microbiota and modulating the immune system, aiming to alleviate the severity of malnutrition-related complications in children. However, achieving optimal efficacy and safety with synbiotics necessitates further rigorous trials. These trials should specifically target refining dosage regimens and formulating compositions conducive to eliciting the desired, safe responses in clinical settings. In conclusion, the exploration of inulin sourced from onion extracts, integrated with supportive therapy focusing on gut microbiota manipulation and immune modulation alongside probiotic-rich dadih, shows immediate potential for practical application in addressing childhood malnutrition.

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Journal Info

Abbrev

art

Publisher

Subject

Health Professions Medicine & Pharmacology Public Health

Description

Majalah Kedokteran Andalas (MKA) (p-ISSN: 0126-2092, e-ISSN: 2442-5230) is a peer-reviewed, open-access national journal published by Faculty of Medicine, Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of medicine ...