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All Journal Majalah Kedokteran Andalas
Refa Rahmaddiansyah
Andalas University
Health Professions Medicine & Pharmacology Public Health

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Preliminary Screening of Phytochemical Compounds of Jeriangau (Acorus calamus) from West Sumatra Refa Rahmaddiansyah; Muhammad Abi Ghoffari Siregar; Rauza Sukma Rita
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p88-95.2023

Abstract

Indonesia's biodiversity is able to meet the needs of human life in various sectors, especially in the utilization of potential plants. Jeriangau (Acorus calamus) is a rhizome plant that is widely used as traditional medicine in various ethnicities, especially in West Sumatra. This is because jeriangau contains bioactive compounds that have the potential to treat various diseases. This research method is an experimental study to qualitatively confirm the bioactive components contained in the rhizome of Jeriangau. The test results of jeriangau simplicia samples showed positive results for the active group of secondary metabolites of flavonoids, tannins, and saponins which have potential as antioxidants. Flavonoids can reduce the risk of chronic disease, especially cardiovascular disease and cancer. Tannins have antioxidant properties and can protect the skin from damage caused by UV radiation. Saponins are known to act as antiviral, antimicrobial, and anti-inflammatory. Therefore, Acorus calamus extract can be used as an antibacterial, antiviral, antiseptic, antifungal, and acts as an antioxidant. Further research is needed on studies of inflammatory activity, either in vitro, in vivo, or in human treatment.Keywords: jeriangau; phytochemicals; West Sumatra; antioxidant.
Harnessing the Potential of Synbiotic Therapy for Childhood Malnutrition: A Narrative Review of Onion Inulin Extracts and Probiotic-Rich Dadih Refa Rahmaddiansyah; Wahida Rahmi; Dessy Arisanty; Rauza Sukma Rita; Sukarsi Rusti
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1875-1886.2024

Abstract

Malnutrition and undernutrition in children are predominantly attributed to insufficient dietary intake and diseases, posing substantial risks without timely intervention. The emerging field of synbiotics, a symbiotic combination of probiotics and prebiotics, presents a promising avenue in nutritional therapy. It effectively modulates the composition and metabolic activities of the intestinal microbiota. This approach aligns seamlessly with the Sustainable Development Goals for 2030, offering a cost-effective strategy for both prophylaxis and immunomodulation. This study delves into a narrative literature review, examining the potential application of an extract derived from onion (Allium cepa Linn.) inulin, coupled with the beneficial attributes of the probiotic-rich traditional Sumatran dadih, as a supportive therapy. The emphasis lies in manipulating the intestinal microbiota and modulating the immune system, aiming to alleviate the severity of malnutrition-related complications in children. However, achieving optimal efficacy and safety with synbiotics necessitates further rigorous trials. These trials should specifically target refining dosage regimens and formulating compositions conducive to eliciting the desired, safe responses in clinical settings. In conclusion, the exploration of inulin sourced from onion extracts, integrated with supportive therapy focusing on gut microbiota manipulation and immune modulation alongside probiotic-rich dadih, shows immediate potential for practical application in addressing childhood malnutrition.
Medical Rehabilitation Program for Knee Osteoarthritis: A Narrative Review Refa Rahmaddiansyah; Riri Prima Yolanda; Rini Agustin
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1887-1899.2024

Abstract

Osteoarthritis, a prevalent form of arthritis linked to bone degeneration, particularly affects the elderly population. In Indonesia, its prevalence rises with age, impacting various ethnic groups, notably women, and leading to substantial disability in individuals aged 65 and older. Vigilance is essential against potential complications like gastritis, bleeding, or kidney issues resulting from prolonged use of non-steroidal anti-inflammatory drugs (NSAIDs). The condition's pathophysiology involves joint aging, injuries, excessive use, genetic predisposition, obesity, and hormonal changes. Its clinical signs develop gradually but can accelerate due to injuries or joint strain, significantly reducing patient productivity and life quality. Managing osteoarthritis involves non-drug approaches like education, physical and exercise therapy, followed by medication and supportive devices. The treatment selection depends on severity and the number of affected joints, aiming to control pain, improve joint function, ease physical limitations, and hinder disease progression and complications. Prompt intervention with suitable modalities aligned with the patient's condition offers a favorable prognosis. Factors like muscle weakness, obesity, and depressive disorders can exacerbate osteoarthritis outcomes. Comprehensive management addressing these factors can significantly improve the prognosis and enhance the patient's quality of life.
Co-Authors Dessy Arisanty Muhammad Abi Ghoffari Siregar Rauza Sukma Rita Rini Agustin Riri Prima Yolanda Sukarsi Rusti Wahida Rahmi