Medula
Vol 14 No 2 (2024): Medula

Tinjauan: Malondialdehyde (MDA) sebagai Marker Stres Oksidatif Berbagai Penyakit

Gusnirwan, Alief (Unknown)
Sangging, Putu Ristyaning Ayu (Unknown)



Article Info

Publish Date
12 Feb 2024

Abstract

Oxidative Stress is a condition of imbalance between free radicals and antioxidants in the body. This can be caused by the excessive production of reactive oxygen species (ROS) or reactive nitrogen species (RNS), which can damage biomolecules such as lipids, proteins, and nucleic acids. Various factors, including environmental elements like UV rays, radiation, pollutants, smoking, heavy metals, and exposure to drugs, can trigger this condition. Malondialdehyde (MDA) serves as a stable and accurate biomarker of oxidative stress and can indicate the oxidation processes within cell membranes. Elevated concentrations of MDA are associated with pathological conditions and can lead to damage to blood vessel walls, the development of heart diseases, changes in cell membrane properties, and DNA mutations, contributing to the formation of cancer and genetic diseases. Numerous studies have shown significantly different MDA levels between healthy individuals and those with specific diseases, and MDA values correlate with the severity of various illnesses. Understanding the mechanisms of oxidative stress and measuring biomarkers like MDA provide crucial insights into the role of oxidative stress in the pathology of diverse diseases, opening avenues for the development of more effective prevention and treatment strategies.

Copyrights © 2024






Journal Info

Abbrev

medula

Publisher

Subject

Education Medicine & Pharmacology Neuroscience Public Health

Description

Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 ...