Aktivitas Anti-Inflamasi In Vitro Ekstrak Etanol Daun Vernonia amygdalina DELILE Dengan Pengujian Stabilisasi Membran

Muhammad Khairul Nuryanto (Laboratorium Ilmu Kedokteran Komunitas, Fakultas Kedokteran, Universitas Mulawarman)
Swandari Paramita (Laboratorium Ilmu Kedokteran Komunitas, Fakultas Kedokteran, Universitas Mulawarman)
Abdillah Iskandar (Laboratorium Mikrobiologi, Fakultas Kedokteran, Universitas Mulawarman)
Sjarif Ismail (Laboratorium Farmakologi, Fakultas Kedokteran, Universitas Mulawarman)
Andre Kusuma Ruslim (Program Studi Pendidikan Dokter Gigi, Fakultas Kedokteran, Universitas Mulawarman)

Jurnal Sains dan Kesehatan
Vol. 1 No. 8 (2017): J. Sains Kes.

Inflammation is a normal process in the human body as a response to injury from the healing process. Meanwhile, chronic inflammation will cause new health problems to patients. Anti-inflammatory agents generally used for those conditions, have several side effects to patients. The objective of this research was to find alternative anti-inflammatory agents, especially from natural sources. Vernonia amygdalina Delile knew locally as “Daun Bismillah” belong to family Apiaceae is one of those potential natural sources for alternative anti-inflammatory agents. This plant is known as traditional medicine and used as material in this research. The experimental method of in vitro anti-inflammatory measurement using membrane stabilization activity for ethanol extracts of V. amygdalina leaves. The results showed that significant differences of EC50 (p<0.05) were achieved between indomethacin as the positive control with V. amygdalina leaves extracts for concentration 1% and 10%. EC50 of leaves ethanol extract of V. amygdalina showed the potential anti-inflammatory activities. It could be concluded that V. amygdalina leaves ethanol extracts to have anti-inflammatory activities, which could be further developed as a new natural source of the anti-inflammatory agents.