Senyawa Alkaloid Furokuinolin dari Kulit Batang Zanthoxylum acanthopodium DC

Tjitjik Tjahjandarie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia)
Alfiah Nur Irza Gunawan (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia)
Ratih Dewi Saputri (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia)
Mulyadi Tanjung (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia)

Jurnal Sains dan Kesehatan
Vol. 2 No. 2 (2019): J. Sains Kes.

Dua senyawa alkaloid furokuinolin, diktammin (1) dan skimmianin (2) telah berhasil diisolasi dari kulit batang Zanthoxylum acanthopodium DC. Penentuan struktur kedua senyawa alkaloid ditetapkan berdasarkan analisis spektrum UV, IR, MS, 1D dan 2D NMR. Uji aktivitas antikanker senyawa 1–2 terhadap sel murine leukemia P-388 memperlihatkan nilai IC50 10,41 dan 4,85 µg/ml.