CYTOTOXIC ACTIVITY AGAINST P-388 MURINE LEUKEMIA CELL FROM Lygodium microphyllum HERB

Hadi Kuncoro (1Departement Of Chemistry, Faculty Of Mathematics and Science, Padjajaran University, Jatinangor 2Pharmaceutical Research & Development Laboratory of FARMAKA TROPIS Pharmacy Faculty, Mulawarman Univesity, Samarinda, East Kalimantan, Indonesia)

Jurnal Farmasi Galenika
Vol 3 No 01 (2016): JURNAL FARMASI GALENIKA

Lygodium microphyllum is an invasive climbing fern weed that has become aggressive in humid habitats in tropical regions. We studied its cytotoxic activity of methanol extract, n-hexane, Ethyl acetate, and n-butanol fraction. Various extract tested for cytotoxic activity on murine P388 leukemia cells using the MTT assay method. The results of the work indicated that IC50 values of methanol extract >100 μg/mL, n-hexane fraction 62,186 μg/mL, Ethyl acetate fraction 50,166 μg/mL , and n-butanol fraction >100 μg/mL on the growth of the P-388 murine leukemia cells.