Indonesian Journal of Applied Research (IJAR)
Vol. 5 No. 3 (2024): Indonesian Journal of Applied Research (IJAR)

In Vitro Study of Red Betel Leaves as Lymphocyte Cell Proliferator and Colorectal Cancer Cytotoxic Agent in Widr Cells

Pratama, Rahadian (Unknown)
Safithri, Mega (Unknown)
Umar, Mutmainnah Agustiawan (Unknown)
Tarman, Kustiariyah (Unknown)

Article Info

Publish Date
31 Dec 2024

Abstract

Colorectal cancer remains a leading cause of mortality worldwide and is closely linked to the immune system, particularly lymphocytes. This study evaluated the ethyl acetate fraction of red betel (Piper crocatum Ruiz & Pav) leaf ethanol extract for its anticancer activity against WiDr colon cancer cells and its effect on lymphocyte cell proliferation. Using MTT assays, the fraction showed significant WiDr cell inhibition (98.18% ± 1.21% at 500 ppm) and enhanced lymphocyte viability (143.3% ± 19.46% at 20 ppm). These results suggest the ethyl acetate fraction serves both as an effective anticancer agent against WiDr cells and as a promoter of lymphocyte proliferation, offering potential for dual therapeutic application.

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Journal Info
Indonesian Journal of Applied Research (IJAR)
Website

Abbrev

IJAR

Publisher

Universitas Djuanda Bogor

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT

Description

Indonesian Journal of Applied Research (IJAR), e-ISSN 2722-6395 is high quality open access peer reviewed research journal that is published by Universitas Djuanda (UNIDA). IJAR dedicated to publish significant research findings in the field of Applied Sciences, Engineering &Technology. We welcome ...