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All Journal Indonesian Journal of Applied Research (IJAR)
Umar, Mutmainnah Agustiawan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT

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In Vitro Study of Red Betel Leaves as Lymphocyte Cell Proliferator and Colorectal Cancer Cytotoxic Agent in Widr Cells Pratama, Rahadian; Safithri, Mega; Umar, Mutmainnah Agustiawan; Tarman, Kustiariyah
Indonesian Journal of Applied Research (IJAR) Vol. 5 No. 3 (2024): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v5i3.522

Abstract

Colorectal cancer remains a leading cause of mortality worldwide and is closely linked to the immune system, particularly lymphocytes. This study evaluated the ethyl acetate fraction of red betel (Piper crocatum Ruiz & Pav) leaf ethanol extract for its anticancer activity against WiDr colon cancer cells and its effect on lymphocyte cell proliferation. Using MTT assays, the fraction showed significant WiDr cell inhibition (98.18% ± 1.21% at 500 ppm) and enhanced lymphocyte viability (143.3% ± 19.46% at 20 ppm). These results suggest the ethyl acetate fraction serves both as an effective anticancer agent against WiDr cells and as a promoter of lymphocyte proliferation, offering potential for dual therapeutic application.
Co-Authors Kustiariyah Tarman Mega Safithri Rahadian Pratama