Medula
Vol 14 No 9 (2024): Medula

Rasio Platelet dan Sel Darah Putih: Implikasinya dalam Patofisiologi Stroke

Azhar, Hafidz Sirojudhin (Unknown)
Kurniati, Intanri (Unknown)
Pramesona, Bayu Anggileo (Unknown)
Utama, Winda Trijayanthi (Unknown)



Article Info

Publish Date
13 Feb 2025

Abstract

Acute ischemic stroke is a leading cause of morbidity and mortality worldwide, significantly impacting patients' quality of life and healthcare systems. Understanding prognostic factors that predict clinical outcomes in acute ischemic stroke patients is crucial, especially with the rising prevalence of risk factors such as hypertension, diabetes, and dyslipidemia. Recent studies have focused on hematological biomarkers, particularly the platelet-to-white blood cell ratio (PWR), which reflects the interaction between immune system components and hemostasis. This literature review examines the prognostic value of PWR in acute ischemic stroke, correlating higher PWR with better clinical outcomes measured by the National Institute of Health Stroke Scale (NIHSS). Lower PWR values have been associated with increased mortality risk within 90 days post-stroke. The dynamics of PWR provide insights into the body's response to ischemia and inflammation, highlighting its potential as a valuable prognostic marker. While PWR shows promise as a prognostic tool, limitations such as individual variability in inflammatory response, timing of measurement, and lack of standardization must be considered. Further research is needed to explore PWR's potential across diverse populations and address existing limitations to enhance its clinical application in managing acute ischemic stroke.

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Journal Info

Abbrev

medula

Publisher

Subject

Education Medicine & Pharmacology Neuroscience Public Health

Description

Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 ...