Schools in Indonesia generally use conventional or traditional learning models, where teaching is still centered around the teacher as the main source of knowledge, while students play a more passive role as recipients of information. The lack of active interaction and student engagement in learning can lead to boredom and a lack of motivation to learn, which can result in lower student achievement. The objective of this study is to determine the effect of implementing the Problem-Based Learning (PBL) model on students' learning outcomes, conducted in Class X at SMA Negeri 8 Makassar on the topic of biotechnology. This research is an experimental study with two independent classes: a control class and an experimental class. Based on the research results and data analysis using SPSS statistics, and hypothesis testing using the Mann-Whitney test, an Asymp. Sig. (2-tailed) value of 0.004 was found. This shows that the Asymp. Sig. (2-tailed) value is less than 0.05, thus Hypothesis 1 is accepted. Therefore, it can be concluded that there is a significant effect of using the Problem-Based Learning model on the learning outcomes of students in Class X at SMA Negeri 8 Makassar, particularly on the topic of biotechnology
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