Mindfulness-based interventions (MBIs) have received increasing attention as effective tools for promoting mental health and psychological resilience. This narrative review explores the effectiveness of MBIs in reducing stress and anxiety, improving emotional regulation, and fostering long-term mental well-being across various populations. Literature was gathered from Scopus, PubMed, and Google Scholar using a comprehensive keyword and Boolean search strategy. Studies were selected based on inclusion criteria focusing on empirical research involving healthcare workers, youth, and vulnerable populations. The findings affirm the effectiveness of MBIs in mitigating stress and anxiety, especially during crises such as the COVID-19 pandemic. Emotional regulation was significantly enhanced among individuals engaging in mindfulness, with outcomes varying based on gender, cultural context, and program design. Long-term benefits were closely associated with the consistency of practice, highlighting the importance of routine engagement. Systemic barriers including organizational resistance, limited training, and lack of resources were identified as key challenges to implementation. The discussion emphasizes the need for evidence-based policies, public education, standardized training, and multi-sectoral collaboration. Ultimately, the review recommends the integration of culturally tailored mindfulness programs into national mental health strategies to enhance accessibility and effectiveness. Future research should target longitudinal and inclusive studies to bridge existing gaps in the literature and inform scalable mental health solutions.
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