This study aims to determine whether there is an effect of the application of the guided inquiry learning model on critical thinking skills in terms of self-esteem. The sampling technique in this study used a random sampling technique and the number of samples was 26 students. Data collection techniques are using test and non-test instruments. The instruments used are tests of students' critical thinking skills, self-esteem questionnaires, and learning implementation observation sheets. The data analysis technique used is descriptive statistical analysis and inferential statistics with simple linear regression analysis. The results showed that: (1) The application of the guided inquiry learning model had no effect on the critical thinking skills of students in the SER category (low self-esteem), (2) The application of the guided inquiry learning model had an effect of 27.3% on the critical thinking skills of students in the SES category ( moderate self-esteem), and (2) the application of the guided inquiry learning model has an effect of 82.8% on the critical thinking ability of students in the SET category (high self-esteem).
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