Pengaruh Ekstrak Buah Naga Merah (Hylocereus polyrhizus) terhadap Kadar HDL Tikus Wistar Model Sindrom Metabolik: Hasil Penelitian

Valensia Putri Melliana (Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta)
Jarot Subandono (Biochemistry Laboratory, Faculty of Medicine, Sebelas Maret University, Surakarta)
Danus Hermawan (Biochemistry Laboratory, Faculty of Medicine, Sebelas Maret University, Surakarta)
R. Prihandjojo Andri Putranto (Biochemistry Laboratory, Faculty of Medicine, Sebelas Maret University, Surakarta)
Sarsono (Biochemistry Laboratory, Faculty of Medicine, Sebelas Maret University, Surakarta)

Cermin Dunia Kedokteran
Vol 51 No 10 (2024): Infeksi

Introduction: Metabolic syndrome is characterized by hypertension, central obesity, insulin resistance, and dyslipidemia. Hylocereus polyrhizus is known for its potential in treating metabolic syndrome. Method: Laboratory experimental study with pretest-posttest control group design. Thirty rats were divided into 5 groups: K1 and K2 as negative and positive control, K3, K4, and K5 as groups receiving red dragon fruit extract at doses of 60, 120, and 180 mg/200 gBW. Data were analyzed using one-way ANOVA, Tukey HSD test, paired T-test, and Pearson correlation. Results: The highest HDL levels were observed in K5, while the lowest was in K1. Pearson correlation revealed a strong relationship between the dose of Hylocereus polyrhizus and HDL levels. Conclusion: Hylocereus polyrhizus extract could significantly increase HDL level. In this study, the optimal dose was 180 mg/200 gBW.