<![CDATA[The prevalence rate of mortality in colorectal cancer is comparatively elevated. A standard or effective treatment has not been developed to resolve this issue. Utilizing Muntingia calabura, which is known to contain rutin with anti-cancer properties, is one of the strategies that can be implemented. The present study focuses on the potential therapeutic effects of M. calabura as an anti-cancer agent in colorectal cancer. Specifically, this study investigates the anti-cancer properties of rutin against colorectal cancer. The results of this study showed that the ethanolic extraction of M. calabura contained approximately 0.727 mg/mL of rutin. Additionally, the cytotoxicity assessment revealed that the rutin fraction was moderately cytotoxic, with a value of 70.808 μg/mL. The results of molecular docking experiments demonstrated a high degree of accuracy in predicting the interaction between rutin and β-catenin. Furthermore, the quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay revealed a significant reduction in the expression of the β-catenin gene within the cells exposed to the extract. In conclusion, M. calabura extract exhibits anti-cancer properties by influencing the WNT signaling pathway in CT26 cells.]]>
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