<![CDATA[The peel of mangosteen (Garcinia mangostana L.) is rich in bioactive compounds, including xanthones, phenolics, flavonoids, anthocyanins, and vitamin C, which have been associated with antioxidant, anti-inflammatory, and anti-aging properties. This study aimed to optimize the extraction of these compounds, particularly xanthones, using Microwave-Assisted Extraction (MAE) in combination with a Natural Deep Eutectic Solvent (NADES) consisting of lactic acid, sodium acetate, and distilled water in a 3:1:2 volume ratio. The extraction process was carried out under varying microwave power levels (300, 375, and 450 Watt) and extraction times (2, 4, and 6 min). Optimization was conducted using Response Surface Methodology (RSM), and the resulting bioactive compound contents were analyzed by UV-Vis spectrophotometry. The optimal extraction conditions were determined at 300 Watt and 4.46 min, resulting in xanthone (1.40%), phenolics (42.43%), flavonoids (1.22%), anthocyanins (1.20%), and vitamin C (2.94%). These findings indicate that NADES-MAE is an effective green extraction technique for maximizing bioactive compounds from mangosteen peel, supporting its potential use in anti-aging product formulations.]]>
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