Jurnal Laboratorium Khatulistiwa
Vol 8, No 2 (2025): Mei 2025

The Effect of Kratom Leaf Alkaloid Extract on Blood Glucose Levels Using an In Vivo Method

Dewi, Bastiana (Unknown)
Kamilla, Laila (Unknown)
Sutriswanto, Sutriswanto (Unknown)
Tumpuk, Sri (Unknown)
Triana, Linda (Unknown)

Article Info

Publish Date
01 Jun 2025

Abstract

Kratom contains alkaloids, flavonoids, saponins, and tannins, which have traditionally been used to boost energy and treat various health conditions, including diabetes. This study aims to analyze the effect of kratom leaf alkaloid extract on blood glucose levels in vivo using a quasi-experimental design. The subjects were 27 male Swiss Webster mice (Mus musculus), divided into three treatment groups receiving kratom leaf alkaloid extract at doses of 0.147 mg/20gBW, 0.294 mg/20gBW, and 0.588 mg/20gBW. The alkaloid extract was obtained through fractionation. Each treatment group was replicated nine times using purposive sampling. An oral glucose tolerance test was conducted to measure blood glucose levels. The Simple Linear Regression test results showed a p-value of 0.000 (p < 0.05), indicating a significant effect of kratom leaf alkaloid extract on blood glucose levels in vivo.

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Journal Info
Jurnal Laboratorium Khatulistiwa
Website

Abbrev

JLK

Publisher

Poltekkes Kemenkes Pontianak

Subject

Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Description

The aim of this journal publication is to disseminate the conceptual thoughts or ideas and research results that have been achieved in the area of Medical Laboratory. Jurnal Laboratorium Khatulistiwa particularly focuses on the main problems in the development of the Medical Laboratory health ...