Acute coronary syndrome (ACS) is the leading cause of death from heart disease worldwide. Several studies have identified risk factors that increase mortality among ACS patients, including advanced age, type 2 diabetes mellitus, and chronic kidney disease. This study aims to evaluate the association between these risk factors and mortality in ACS patients at Hospital X Jakarta between September 2023 and September 2024. Contains This study used a retrospective cohort design with analysis of medical record data of patients with ACS. Statistical analysis was performed using chi-squared and Fisher's exact tests to determine the association of age, type 2 diabetes mellitus, and chronic kidney disease with mortality in patients with ACS. Contains A total of 84 patients with a mean age of 59.49 years met the study criteria. The majority of patients had NSTEMI (61.9%) and 56% had type 2 diabetes mellitus. Mortality occurred in 4.8% of the patients. The results of the analysis showed that advanced age (≥60 years) was significantly associated with mortality in SCA patients (p=0.047; RR=4.50). Chronic kidney disease was also significantly associated with mortality (p=0.011; RR=8.16). However, type 2 diabetes mellitus did not show a significant association with mortality (p=0.092). Advanced age and chronic kidney disease were significant predictors of mortality in patients with ACS, whereas type 2 diabetes mellitus was not significantly associated with mortality.
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