Mandala of Health : A Scientific Journal
Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal

CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY: A COMPREHENSIVE REVIEW OF PATHOPHYSIOLOGY, CLINICAL MANIFESTATIONS AND MANAGEMENT STRATEGIES

Aulia, Rashieka Salma (Unknown)
Indriawan, Ramses (Unknown)

Article Info

Publish Date
30 Sep 2025

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapy that damages peripheral nerves, causing sensory, motor, and autonomic abnormalities that significantly decrease the quality of life for cancer patients. Characterized by symptoms such as numbness and tingling, the incidence of CIPN can reach 68% in the first month post-therapy. The severity of this condition often forces a dose reduction or discontinuation of chemotherapy, which can compromise the effectiveness of cancer treatment. Based on this literature review of the last 10 years, CIPN is a significant clinical challenge. Therefore, comprehensive clinical guidelines for its diagnosis, symptom management, and prevention are needed to optimize cancer therapy outcomes

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Journal Info
Mandala of Health : A Scientific Journal
Website

Abbrev

mandala

Publisher

Universitas Jenderal Soedirman

Subject

Dentistry Health Professions Public Health

Description

Mandala of Health : A Scientific Journal is a medical scientific journal with open access published by the Faculty of Medicine, Jenderal Soedirman University, containing research articles, systematic reviews, and case reports in all areas of basic medical science, clinical medicine, biomedical ...