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All Journal Jurnal Biologi Tropis Mandala of Health : A Scientific Journal
Aulia, Rashieka Salma
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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THE IMMUNE RESPONSE TO HUMAN IMMUNODEFICIENCY VIRUS Nuriasti, Rovera; Putri, Dyah Arista; Aulia, Rashieka Salma
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.15497

Abstract

Human Immunodeficiency Virus (HIV) is an infectious agent that disrupts the immune system by destroying CD4+ T lymphocytes, thereby triggering a decline in immune function and the development of Acquired Immunodeficiency Syndrome (AIDS). HIV employs a complex infection mechanism, including binding to host cell receptors, integration of genetic material, and modulation of the immune system to evade detection. The immune response to HIV involves the innate immune system, such as the activation of macrophages and dendritic cells through pattern recognition receptors, as well as the adaptive immune system through the activity of cytotoxic T cells and antibody production by B cells. However, HIV utilizes various strategies to evade immune responses, including rapid mutation and down-regulation of immune molecule expression. Antiretroviral therapy (ART) is the primary strategy for inhibiting HIV replication and maintaining immune system function, and it has been proven effective in reducing the morbidity and mortality associated with HIV infection, although a curative therapy has yet to be discovered.
CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY: A COMPREHENSIVE REVIEW OF PATHOPHYSIOLOGY, CLINICAL MANIFESTATIONS AND MANAGEMENT STRATEGIES Aulia, Rashieka Salma; Indriawan, Ramses
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17802

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapy that damages peripheral nerves, causing sensory, motor, and autonomic abnormalities that significantly decrease the quality of life for cancer patients. Characterized by symptoms such as numbness and tingling, the incidence of CIPN can reach 68% in the first month post-therapy. The severity of this condition often forces a dose reduction or discontinuation of chemotherapy, which can compromise the effectiveness of cancer treatment. Based on this literature review of the last 10 years, CIPN is a significant clinical challenge. Therefore, comprehensive clinical guidelines for its diagnosis, symptom management, and prevention are needed to optimize cancer therapy outcomes
Understanding Precocious Puberty: When Childhood Ends Too Soon Muliana, Atriska Citra; Putri, Imey Pinasty Harianto; Prasetya, Rangga Cahya; Indratama, I Nyoman Yudayana; Athalia, Ihza Namira; Shafitri, Shira Shalsabina; Mertasari, Baiq Merna; Josafat, Gantha Narendra; Ilmiah, Janiya Abdila; As Shiddiq, Muhammad Hilmy; Aulia, Rashieka Salma; Ajmala, Indana Eva
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10337

Abstract

Precocious puberty is an endocrine disorder characterized by the premature development of secondary sexual characteristics, defined as occurring before the age of 8 in girls and 9 in boys. This literature review aims to understand precocious puberty: when childhood ends too soon. The article was compiled using a literature review method. Data were obtained through a search of various scientific sources, including international and national journals, textbooks, and clinical guidelines from the Indonesian Pediatrician Association (IDAI). Central precocious puberty, most often idiopathic in girls but associated with underlying pathology in boys, is caused by premature activation of the hypothalamic-pituitary-gonadal axis, while the peripheral form is caused by excess sex steroid production independent of gonadotropin stimulation. Clinical manifestations include early breast development, testicular enlargement, rapid linear growth, acne, and the early appearance of pubic or axillary hair. Diagnosis relies on a combination of careful history taking, physical examination, hormonal testing, bone age assessment, and imaging studies such as pelvic ultrasound or cranial MRI when indicated. Management strategies vary based on etiology, with gonadotropin-releasing hormone (GnRH) agonists being the standard treatment for central precocious puberty, while surgical or medical therapy is used for peripheral causes. In conclusion, precocious puberty is a childhood health issue of increasing concern due to its increasing global incidence. This condition not only impacts accelerated bone maturation and potential short stature in adulthood, but also impacts the child's psychological well-being and causes emotional distress to the family.
Case Study of Bilateral Ureteral Stones Complicated by Acute Kidney Injury in a 52-Year-Old Female Patient Ilmiah, Janiya Abdila; Putri, Imey Pinasty Harianto; Muliana, Atriska Citra; Athalia, Ihza Namira; Shafitri, Shira Shalsabina; Sari, Baiq Merna Merta; Aulia, Rashieka Salma; Prasetya, Rangga Cahya; Indratama, I Nyoman Yudayana; Shiddiq, Muhammad Hilmy As; Josafat, Gantha Narendra
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10344

Abstract

Bilateral ureteral stones are a rare clinical manifestation of renal colic, obstructing urine flow, and can cause severe acute kidney injury (AKI) within hours. This case study aims to provide information regarding the diagnosis and management of bilateral ureteral stones causing acute kidney injury in a 52-year-old female patient. This case study uses a descriptive method to describe the current situation, for further analysis and interpretation. Based on anamnesis and physical examination, the patient was diagnosed with Acute Kidney Injury (AKI) stage 3 with a differential diagnosis of Advanced Chronic Kidney Disease (ACKD) stage 4. This condition is caused by urinary tract obstruction due to bilateral ureterolithiasis (stones in both ureters) and proximal right ureteral stenosis, which inhibits urine flow and worsens kidney function acutely and chronically. Complaints of right and left abdominal pain, as well as a history of urinary tract infections (UTIs) and hypertension, support the formation of stones in the urinary tract. The conclusion is that the patient Wirni/P/52 years old/AKI stage 3 dd ACKD stage 4 dt obstructive uropathy + ureterolithiasis infection + normocytic normochromic anemia dt chronic disease + bilateral ureteral stones + right proximal ureteral stenosis.
Co-Authors Ajmala, Indana Eva As Shiddiq, Muhammad Hilmy Athalia, Ihza Namira Ilmiah, Janiya Abdila Indratama, I Nyoman Yudayana Indriawan, Ramses Josafat, Gantha Narendra Mertasari, Baiq Merna Muliana, Atriska Citra Nuriasti, Rovera Prasetya, Rangga Cahya Putri, Dyah Arista Putri, Imey Pinasty Harianto Sari, Baiq Merna Merta Shafitri, Shira Shalsabina Shiddiq, Muhammad Hilmy As