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All Journal Mandala of Health : A Scientific Journal
Indriawan, Ramses
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Dentistry Health Professions Public Health

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CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY: A COMPREHENSIVE REVIEW OF PATHOPHYSIOLOGY, CLINICAL MANIFESTATIONS AND MANAGEMENT STRATEGIES Aulia, Rashieka Salma; Indriawan, Ramses
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17802

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapy that damages peripheral nerves, causing sensory, motor, and autonomic abnormalities that significantly decrease the quality of life for cancer patients. Characterized by symptoms such as numbness and tingling, the incidence of CIPN can reach 68% in the first month post-therapy. The severity of this condition often forces a dose reduction or discontinuation of chemotherapy, which can compromise the effectiveness of cancer treatment. Based on this literature review of the last 10 years, CIPN is a significant clinical challenge. Therefore, comprehensive clinical guidelines for its diagnosis, symptom management, and prevention are needed to optimize cancer therapy outcomes
Co-Authors Aulia, Rashieka Salma