This study analyzes the implementation of the Hospital Management Information System (SIMRS) at Prof. Dr. H. M. Anwar Makkatutu Regional Hospital, Bantaeng Regency, South Sulawesi, focusing on infrastructure, human resources (HR), and operational procedures. SIMRS is designed to integrate hospital services, administration, and management to improve efficiency and healthcare quality. Using a descriptive qualitative method with a case study approach, data were collected through in-depth interviews and direct observation of hospital management, SIMRS staff, and service users. Thematic analysis was conducted to identify obstacles, supporting factors, and the role of management. The findings show that SIMRS implementation remains suboptimal. Key obstacles include internet and server disruptions, limited computer facilities, and inadequate number and competence of HR. Technical training is infrequent, and SOP application is inconsistent due to technical issues and system incompatibility. Supporting factors include management support, system integration between units, and basic operator understanding of the Kanza application. In conclusion, SIMRS success depends on infrastructure readiness, HR capacity, and procedural consistency. A sustainable integration strategy is required to overcome these barriers and strengthen the hospital information system for optimal service delivery.
                        
                        
                        
                        
                            
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