<![CDATA[Methamphetamine is powerful addictive stimulant that poses significant public health and social challenges, requiring accurate identification for forensic studies and medical assesments. Hait analysis offers a non-invasive way to assess long-term drug use. This research analyzed methamphetamine concentrations in hair samples from drug users using sonication-assisted extraction and subsequent purification of the extract via column chromathography. A combination of methanol, acetone, and ammonia was employed to extract four hair samples (5:1,2:0,08), identified as the most effective solvent system. The compounds were the separated by processing the extracts through column chromatograpghy. The acquired fractions were tested using marquis reagent. Every sample uniformly displayed a distinct yellowish-brown color when combined with the marquis reagent, signifying the presence of the methamphetamine. The efficiency of this method was attributed to the joint effect of sonication, which aids in analyte release, and the improved solvent system. This study highlighted the potential to integrate sonication-assisted extraction with column chromathrograpghy and marquis reagent for the precise detection of methamphetamine in complex hair matrices, essential for forensic toxicology and clinical analysis.]]>
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