Indonesian Journal for Health Sciences (IJHS)
Vol 8 No 1 (2024): March

ATTENUATION OF CIGARETTE-SMOKE-INDUCED OXIDATIVE STRESS BY OAT DIET

Soetedjo, Farida Anggraini (Unknown)
Kristijanto, Johanes Aprilius Falerio (Unknown)
Khamidah, Nur (Unknown)



Article Info

Publish Date
25 Mar 2024

Abstract

Even after cessation of cigarette smoke exposure, long-term exposure leads to lung fibrous tissue growth characteristically by oxidative stress. Oat, an inexpensive dietary source with antioxidant characteristics, is expected to alleviate oxidative stress in the lung tissue after exposure to cigarette smoke has ceased. This research aims to evaluate the effect of an oat diet in alleviating oxidative stress in the lung tissue of BALB/c mice after cessation of cigarette smoke exposure. A randomized post-test-only control group design was used for this research. The sample used in this experiment is male BALB/c mice (n = 33). Mice with BALB/c strain were separated into two groups: (1) control and (2) treatment. SOD, GSH, and MDA were the variables of the study. Cigarette smoke exposure decreases the activity of SOD and GSH and increases the concentration of MDA. After cigarette smoke exposure had been stopped in the oat-treated mice group, SOD and GSH activities were enhanced, and the MDA content dropped. This research's variable outcomes were statistically significant (P<0.05) from the standard feed alone-treated BALB/c mice group. Thus, consuming oats may alleviate oxidative stress implicated in lung fibrogenesis following cessation of tobacco smoke exposure

Copyrights © 2024






Journal Info

Abbrev

IJHS

Publisher

Subject

Nursing Public Health

Description

The Indonesia Journal for Health Sciences publishes articles that report novel findings of health in the areas of : Nursing Midwifery Public health Medicine Pharmacy Biochemistry Molecular biology related drug ...