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All Journal AcTion: Aceh Nutrition Journal Indonesian Journal for Health Sciences (IJHS) Jurnal Health Sains COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Jurnal Sehat Indonesia (JUSINDO) Eduvest - Journal of Universal Studies Blantika : Multidisciplinary Journal Calvaria Medical Journal Prosiding Seminar Nasional COSMIC Kedokteran
Farida Anggraini Soetedjo
Department Of Internal Medicine, Faculty Of Medicine, Universitas Wijaya Kusuma Surabaya
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Pembentukan “Pondok Paru Sehat” Sebagai Pusat Edukasi dan Deteksi Dini Penyakit Paru Obstruktif Kronis, Asma, dan Tuberkulosis di Kelurahan Dukuh Kupang Kota Surabaya Farida Anggraini Soetedjo; Muzaijadah Retno Arimbi; Nur Khamidah; Johanes Aprilius Falerio Kristijanto
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 3 (2024): COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v4i3.1391

Abstract

The Forum of International Respiratory Societies melaporkan penyakit paru obstruktif kronis (PPOK), asma, dan tuberkulosis (TB) masih menjadi penyebab utama kematian dan disabilitas di dunia. Di Indonesia, Riset Kesehatan Dasar (Riskesdas) 2018 menunjukkan preval_ensi ketiga penyakit tersebut masih tinggi, sedangkan penelitian terbaru melaporkan bahwa masih banyak kasus PPOK, asma, dan TB yang tidak terdeteksi (underdiagnosed). Riskesdas 2018 juga melaporkan bahwa rata-rata penderita penyakit tersebut berada pada kelompok usia produktif dan lansia. Upaya promotif, preventif, dan deteksi dini dini masih menjadi kunci utama dalam menurunkan angka mortalitas dan morbiditas serta meningkatkan kualitas hidup. Oleh karena itu, pengabdian kepada masyarakat melalui pembentukan “Pondok Paru Sehat” bertujuan sebagai sarana edukasi dan deteksi dini PPOK, asma, dan TB di Kelurahan Dukuh Kupang Kota Surabaya. Mitra ini dipilih karena memiliki jumlah penduduk usia produktif dan lansia mencapai 11.775 individu yang berisiko menderita ketiga penyakit tersebut. Selain itu, Kelurahan Dukuh Kupang dipilih sebagai wujud pelaksanaan tri dharma Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya (FK UWKS) terhadap masyarakat sekitar. Kegiatan ini melibatkan Departemen Ilmu Penyakit Dalam dan Ilmu Kesehatan Masyarakat FK UWKS serta sebagai implementasi Mata Kuliah / Blok Respiratory System (RS) oleh mahasiswa semester 4 FK UWKS. Edukasi dilakukan dengan pemaparan materi oleh dosen FK UWKS dan dilanjutkan skrining PPOK melalui kuesioner skor PUMA yang disediakan oleh Perhimpunan Dokter Paru Indonesia (PDPI), kuesioner CAPTURE, dan pemeriksaan Peak Expiratory Flow Rate (PEFR) / Arus Puncak Ekspirasi (APE) untuk mengestimasi fungsi paru, sedangkan skrining asma dan TB dilakukan melalui kuesioner.
ATTENUATION OF CIGARETTE-SMOKE-INDUCED OXIDATIVE STRESS BY OAT DIET Soetedjo, Farida Anggraini; Kristijanto, Johanes Aprilius Falerio; Khamidah, Nur
Indonesian Journal for Health Sciences Vol 8, No 1 (2024): March
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v8i1.6599

Abstract

Even after cessation of cigarette smoke exposure, long-term exposure leads to lung fibrous tissue growth characteristically by oxidative stress. Oat, an inexpensive dietary source with antioxidant characteristics, is expected to alleviate oxidative stress in the lung tissue after exposure to cigarette smoke has ceased. This research aims to evaluate the effect of an oat diet in alleviating oxidative stress in the lung tissue of BALB/c mice after cessation of cigarette smoke exposure. A randomized post-test-only control group design was used for this research. The sample used in this experiment is male BALB/c mice (n = 33). Mice with BALB/c strain were separated into two groups: (1) control and (2) treatment. SOD, GSH, and MDA were the variables of the study. Cigarette smoke exposure decreases the activity of SOD and GSH and increases the concentration of MDA. After cigarette smoke exposure had been stopped in the oat-treated mice group, SOD and GSH activities were enhanced, and the MDA content dropped. This research's variable outcomes were statistically significant (P0.05) from the standard feed alone-treated BALB/c mice group. Thus, consuming oats may alleviate oxidative stress implicated in lung fibrogenesis following cessation of tobacco smoke exposure
SUPLEMENTASI GANDUM SEBAGAI UPAYA ATENUASI INFLAMASI SISTEMIK PADA SERUM MENCIT PASCA PENGHENTIAN PAJANAN ASAP ROKOK Farida Anggraini Soetedjo; Johanes Aprilius Falerio; Sunarjo
Prosiding Seminar Nasional COSMIC Kedokteran Vol 2 (2024): Edisi 2024
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pajanan asap rokok atau Environmental Tobacco Smoke (ETS) masih menjadi masalah kesehatan di seluruh dunia. Global Adult Tobacco Survey (GATS) tahun 2021 melaporkan jumlah perokok pasif dewasa di Indonesia mencapai 198 juta individu. Pajanan ETS memiliki efek buruk pada remodeling dan respon inflamasi paru-paru. Gandum memiliki banyak nutrisi dan senyawa bioaktif yang dikaitkan dengan aktivitas anti-oksidan dan anti-inflamasi. Penelitian ini bertujuan untuk mengevaluasi efek suplementasi gandum terhadap inflamasi yang terjadi secara sistemik akibat pajanan asap rokok. Tiga puluh tiga mencit BALB/c jantan dipisahkan menjadi dua kelompok: kontrol dan perlakuan. IL-1β bahan serum merupakan variabel penelitian ini. Konsentrasi IL-1β serum diukur dengan ELISA. Pajanan asap rokok menyebabkan inflamasi secara sistemik. Proses inflamasi tetap berlangsung walupun pajanan asap rokok telah dihentikan, ditandai dengan peningkatan konsentrasi IL-1β pasca penghentian pajanan asap rokok. Suplementasi gandum mampu menekan inflamasi setelah penghentian pajanan asap rokok dengan menurunkan konsentrasi IL-1β. Hasil variabel penelitian ini bermakna secara statistik (p < 0.05) dari kelompok mencit yang tidak mendapatkan terapi gandum. Dengan demikian, mengonsumsi gandum dapat meringankan inflamasi yang terjadi secara sistemik pasca penghentian pajanan asap rokok.
Pengaruh Pemberian Ekstrak Peperomia pellucida Terhadap Penurunan Ekspresi Tumor Necrosis Factor Alpha (TNF-α) Pada Ginjal Tikus Wistar Jantan Yang Mendapat Pajanan Asap rokok Nerawati, Maria Fransiska; Farida Anggraini Soetedjo; Heru Setiawan
Calvaria Medical Journal Vol 2 No 2 (2024): Edisi Desember 2024
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v2i2.119

Abstract

Introduction: Exposure to cigarette smoke causes oxidative stress and inflammatory responses through free radicals. Tumor Necrosis Factor Alpha is a pro-inflammatory cytokine that exacerbates kidney inflammation. The administration of exogenous antioxidants and anti-inflammatory agents is expected to prevent kidney injury caused by cigarette smoke exposure. Peperomia pellucida, also known as "sirih cina," is a plant known for its antioxidant and anti-inflammatory activities. This study aims to investigate the effect of Peperomia pellucida extract on the reduction of TNF-α expression in the kidneys of male Wistar rats exposed to cigarette smoke.Methods: This true experimental study used a post-test only control group design with male Wistar rats aged 8-12 weeks, obtained from the Experimental Animal Laboratory of the Faculty of Medicine, Wijaya Kusuma University, Surabaya. The sample consisted of 20 rats meeting the inclusion and exclusion criteria, with a body weight of approximately 180-200 grams. Data were analyzed using the Mann-Whitney test.Results: The Mann-Whitney test showed a significant difference between groups P1 and P2, with a significance value of 0.025. This indicates that the administration of Peperomia pellucida extract significantly reduced TNF-α expression in the kidneys of rats exposed to cigarette smoke.Conclusion: Administration of Peperomia pellucida extract at a dose of 400 mg/kg/day can reduce TNF-α expression in the kidneys of male Wistar rats exposed to cigarette smoke.
Folinic acid and autism spectrum disorder in children: A systematic review and meta-analysis of two double-blind randomized placebo-controlled trials Farida Anggraini Soetedjo; Johanes Aprilius Falerio Kristijanto; Fara Disa Durry
AcTion: Aceh Nutrition Journal Vol 10, No 1 (2025): March
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i1.1743

Abstract

Folic acid is a synthetic vitamin B9 that plays an important role in folate metabolism, including the synthesis of DNA and RNA, and epigenetic methylation. These processes are essential for the development of the nervous system. Impaired folate metabolism contributes to the pathophysiology of ASD through the dysregulation of neurochemical and epigenetic processes. This meta-analysis aimed to evaluate the efficacy of folinic acid in alleviating ASD symptoms.  Methods: Review Manager Software. Searches were conducted in PubMed, Science Direct, and Cochrane based on studies published in the last five years (2018-2023), with inclusion criteria of RCTs and exclusion of observational studies and non-English articles. Fixed-effects analysis was used because no heterogeneity was observed. Results: Two studies (n= 103) evaluated the effect of folinic acid on reducing ASD symptoms. Symptoms were assessed using the aberrant behavior checklist. The pooled mean difference was -0,66, with a 95% confidence interval ranging from -1,22 -0,10. The results showed statistical significance, with a p-value of 0,02. However, this analysis used only two studies with small sample sizes and modest mean differences. In conclusion, folinic acid administration has the potential to reduce ASD symptoms in children. Further research with a larger sample size is needed to generalize the clinically meaningful results.
Hubungan Usia dan Jenis Kelamin dengan Tekanan Darah Serta Kadar Glukosa Darah pada Masyarakat di Desa Made Kota Surabaya Khamidah, Nur; Anggraini Soetedjo, Farida; Falerio Kristijanto, Johanes Aprilius; Siswoyo, Siswoyo
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 5 No. 3 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v5i3.3251

Abstract

Deteksi Dini Hipertensi dan Hiperglikemia Berbasis Komunitas di Desa Made Kota Surabaya Sebagai Upaya Pencegahan Penyakit Tidak Menular Kristijanto, Johanes Aprilius Falerio; Soetedjo, Farida Anggraini; Khamidah, Nur; Siswoyo , Siswoyo
Blantika: Multidisciplinary Journal Vol. 3 No. 8 (2025): Special Issue
Publisher : PT. Publikasiku Academic Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57096/blantika.v3i8.394

Abstract

Penyakit tidak menular (PTM) seperti hipertensi dan hiperglikemia merupakan penyebab utama morbiditas dan mortalitas di Indonesia. Deteksi dini berbasis komunitas menjadi langkah strategis untuk mencegah komplikasi yang lebih serius. Penelitian ini bertujuan untuk mengidentifikasi tingkat risiko hipertensi dan hiperglikemia melalui pendekatan pemeriksaan kesehatan berbasis komunitas. Metode yang digunakan meliputi skrining tekanan darah, pengukuran kadar gula darah, wawancara kesehatan, serta edukasi gaya hidup sehat. Hasil penelitian menunjukkan bahwa sebagian besar masyarakat memiliki tingkat kesadaran yang rendah terhadap faktor risiko PTM, namun setelah dilakukan skrining dan edukasi, terjadi peningkatan pengetahuan serta kesadaran mengenai pentingnya pencegahan. Kegiatan ini juga menghasilkan data awal mengenai prevalensi risiko hipertensi dan hiperglikemia di tingkat komunitas. Upaya ini diharapkan dapat menjadi model pemberdayaan masyarakat dalam pencegahan PTM secara mandiri dan berkelanjutan.
Clinical Features and Management of Community-Acquired Pneumonia (CAP) In The Elderly Arimbi, Muzaijadah Retno; Amori, Lakcandra Amar; Soetedjo, Farida Anggraini; Haryanti, Elizabeth; Yaniari, Roethmia
Jurnal Health Sains Vol. 6 No. 8 (2025): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v6i8.2657

Abstract

Community-Acquired Pneumonia (CAP) or pneumonia acquired outside health facilities is one of the main causes of morbidity and mortality in the elderly age group. As we age, immune function decreases and is accompanied by comorbidities such as diabetes, heart disease, and chronic lung disease that worsen the course of the disease. This study aims to find out the clinical picture and management of Community-Acquired Pneumonia (CAP) in the elderly. This study uses qualitative research methods. The data collection technique in this study is by studying case report documents. The data that has been collected is then analyzed in three stages, namely data reduction, data presentation and drawing conclusions. The results show that Community-Acquired Pneumonia (CAP) in the elderly is a complex condition with challenges in diagnosis and management, as the symptoms are often atypical and involve various risk factors. Clinical guidelines emphasize the importance of basic supporting examinations such as thoracic imaging and organ function evaluations, as well as prompt and appropriate administration of empirical antibiotics. Treatment should be adjusted to the severity of the patient's frailty, comorbidities, and frailty status. Supportive therapy plays an important role in recovery, while an individualized approach based on risk factors such as malnutrition, sarcopenia, and aspiration is needed to improve prognosis and lower mortality in the elderly with CAP.
Circulating Microrna-19 as a Non-Invasive Biomarker for Detecting Lung Cancer: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies Soetedjo, Farida Anggraini; Khamidah, Nur; Kristijanto, Johanes Aprilius Falerio; Sanjaya, Febrisma Bangun
Eduvest - Journal of Universal Studies Vol. 5 No. 8 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i8.51965

Abstract

Invasive procedures remain the gold standard for lung cancer diagnosis, while new cases in 2018 reached 30,023 patients and tend to occur at a younger age, necessitating non-invasive markers for early detection of lung cancer. Currently, numerous studies have been conducted on microRNA (miRNA) as a lung cancer biomarker, including miRNA-19; however, research findings on miRNA-19 in the diagnosis of this disease remain controversial, prompting this study to assess the ability of miRNA-19 to detect lung cancer through a meta-analysis. Literature searches were conducted in three databases (PubMed, Science Direct, and Cochrane) up to March 22, 2023, using the Patient, Intervention, Comparison, Outcome (PICO) principle, with inclusion criteria for prospective, retrospective, case-control, or cross-sectional studies providing data for analyzing the diagnostic capability of miRNA-19. The methods used adhere to the 2020 PRISMA guidelines. Analysis was performed using STATA, MetaDisc, and Review Manager software. Four articles met the inclusion criteria for this meta-analysis. The combined analysis results regarding the sensitivity of miRNA-19 in lung cancer diagnosis reached 0.81 (95% CI [confidence interval]: 0.76–0.85), specificity 0.69 (95% CI: 0.61–0.76), diagnostic odds ratio (DOR) 12.62 (95% CI: 4.73–33.65), and area under the curve (AUC) 0.85. Analysis of the positive likelihood ratio (PLR) and negative likelihood ratio (NLR) yielded results... Analysis of the positive likelihood ratio (PLR) and negative likelihood ratio (NLR) yielded results 2.51 (95% CI: 1.59–3.95) and 0.29 (95% CI: 0.18–0.48). Based on the above data, miRNA-19 has potential in the non-invasive diagnosis of lung cancer.
Efek Protektif Ekstrak Peperomia pellucida terhadap Fibrosis Jantung yang Diinduksi Pajanan Asap Rokok: Suatu Studi Pre-Klinis Aska, Andra Agnez Al; Soetedjo, Farida Anggraini; Kristijanto, Johanes Aprilius Falerio
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 2 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v7i2.299

Abstract

Fibrosis jantung merupakan respon patologis terhadap cedera kronis yang dapat menyebabkan gangguan fungsi jantung. Pajanan asap rokok atau secondhand smoke (SHS) diketahui dapat meningkatkan risiko fibrosis jantung melalui mekanisme stres oksidatif dan inflamasi. Penelitian ini bertujuan untuk mengevaluasi efek protektif ekstrak Peperomia pellucida terhadap fibrosis jantung yang diinduksi oleh pajanan SHS pada tikus Wistar. Tikus dibagi menjadi tiga kelompok: Kelompok K (kontrol), Kelompok P1 yang hanya menerima pajanan SHS, dan Kelompok P2 yang diberi ekstrak P. pellucida 400 mg/kg BB sebelum dan selama pajanan SHS. Efek fibrosis jantung dievaluasi melalui pengukuran berat jantung dan analisis fraksi area kolagen menggunakan pewarnaan Masson’s Trichrome. Data dianalisis dengan uji One-Way ANOVA diikuti dengan uji post-hoc Tukey. Hasil penelitian menunjukkan bahwa pajanan SHS secara signifikan (p > 0,05) meningkatkan berat jantung dan fraksi area kolagen pada kelompok P1 dibandingkan dengan kelompok kontrol (K). Sementara itu, pada kelompok P2 yang mendapat ekstrak P. pellucida, terdapat penurunan yang bermakna (p < 0,05) pada berat jantung dan fraksi area kolagen. Penurunan ini mengindikasikan adanya efek protektif dari ekstrak P. pellucida. Berdasarkan temuan ini, ekstrak P. pellucida menunjukkan potensi sebagai agen terapeutik dalam mencegah fibrosis jantung yang disebabkan oleh pajanan asap rokok. Penelitian lebih lanjut diperlukan untuk mengeksplorasi mekanisme molekuler yang mendasari efek protektif ini dan untuk menilai dosis serta durasi pengobatan yang optimal.
Co-Authors Amori, Lakcandra Amar Aprilius Falerio Kristijanto, Johanes Arimbi, Muzaijadah Retno Aska, Andra Agnez Al Elizabeth Haryanti Fara Disa Durry HERU SETIAWAN Johanes Aprilius Falerio Johanes Aprilius Falerio Kristijanto Muzaijadah Retno Arimbi Nerawati, Maria Fransiska Nur Khamidah Nur Khamidah Retno Arimbi, Muzaijadah Sanjaya, Febrisma Bangun Siswoyo , Siswoyo Siswoyo Siswoyo Sunarjo Yaniari, Roethmia