Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Vol 17 No 2 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung

FORMULATION AND EVALUATION OF THE PHYSICAL QUALITY OF NIACINAMIDE GEL PREPARATIONS USING PVP AS A GELLING AGENT

Zulananta, Shohihunnatiq (Unknown)
Ginaris, Rifkarosita Putri (Unknown)
Nurrahman, Alfina (Unknown)



Article Info

Publish Date
31 Oct 2025

Abstract

Niacinamide is the amide form of vitamin B3. Other forms of vitamin B3 include niacin (nicotinic acid). Polyvinylpyrrolidone (PVP) is a biodegradable and air-soluble polymer derived from the monomer N-vinylpyrrolidone. Gels are water-rich preparations and have better potential as topical drug delivery preparations compared to ointments because they are non-sticky, require low energy during formulation, are stable, and have aesthetic value. The purpose of this study was to evaluate the physical qualities of PVP-based niacinamide gel preparations based on physical quality parameters, including organoleptic test, ligninogenicity test, pH test, viscosity test, adhesiveness test, and spreading power test. The method used in this study was an experimental method carried out to determine the physical qualities of a good gel. The results of the study showed that the PVP-based niacinamide gel preparation produced had a thick gel texture, transparent color, odorless, homogeneous, an average pH value of 16.6, an average viscosity value of 2673.6 - 2179.6, an average spreadability value of 6.2 - 6.3, and an average adhesiveness value of 4.67 - 4.46. Based on these results, the PVP-based niacinamide gel preparation had physical quality that met the requirements according to good criteria.

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Journal Info

Abbrev

jrk

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Description

Jurnal Riset Kesehatan Poltekkes Depkes Bandung menerima publikasi dalam makalah penelitian artikel asli, makalah tinjauan, laporan kasus di Indonesia atau negara lain untuk memberikan pemahaman mengenai aspek kesehatan. Ruang lingkup Artikel yang diterbitkan dalam jurnal ini adalah bidang : - ...