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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Farmasi Indonesia Jurnal Riset Kesehatan Poltekkes Depkes Bandung Abdimasku : Jurnal Pengabdian Masyarakat Bioscientist : Jurnal Ilmiah Biologi JAGO TOLIS : Jurnal Agrokompleks Tolis Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Agroteknologi Jurnal Pengabdian dan Pengembangan Masyarakat Indonesia Jurnal Relawan dan Pengabdian Masyarakat REDI Jurnal Pengabdian Masyarakat Ilmu Kesehatan Jurnal Paradigma Pengabdian Pharmacia Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah Jurnal Kesehatan Tujuh Belas (Jurkes TB)
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Optimasi Formula Lotion Ekstrak Etanol Bunga Krisan (Crhysanthemum cinerariaefolium (Trevir.)Vis.) menggunakan Kombinasi Asam Stearat dan Setil Alkohol sebagai Repelan dengan Metode Simplex Lattice Design Rifkarosita Putri Ginaris; Rina Herowati; TN Saifullah Sulaiman
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.857

Abstract

Chrysanthemum flower (Crhysanthemum cinerariaefolium (Trevir.) Vis.) contains flavonoids, saponins and polyphenols which are efficacious as repellents against Aedes aegypti mosquitoes. Lotions with a combination of stearic acid and cetyl alcohol are used to improve adhesion and thickening. The purpose of this study was to make a lotion preparation using a combination of stearic acid and cetyl alcohol to obtain optimum physical quality and obtain an effective concentration of chrysanthemum flower extract as a repellant lotion against A. aegypti mosquitoes and a safe effect on the skin. Chrysanthemum extraction was carried out using 70% ethanol. Chrysanthemum ethanol extract was then dose oriented with a concentration of 1.2%. Chrysanthemum flower ethanol extract lotion formulations were made into 7 formulations using stearic acid and stearic acid bases, Formula I 9.00: 8.00%, Formula II 15.00: 2.00%, Formula III 11.00: 6.00 %, Formula IV 15.00: 2.00%, Formula V 13.00: 4.00%, Formula VI 7.00: 10.00%, Formula VII 11.00: 6.00%. Determination of the optimum formula using the Simplex Lattice Design method using the Design Expert program. The optimum formula is obtained, then tested for physical stability including viscosity, adhesion, dispersion and pH. Physical stability was tested using the One Way Anova method followed by Tuckey HSD. Irritation test with the method of Human 4-hour patch test and hedonic test by giving questions to probandus. Chrysanthemum extract concentration of 1.2% has pharmacological activity that functions as a repellent power of mosquitoes. The optimum combination of stearic acid and cetyl alcohol, 7% stearic acid and 10% cetyl alcohol, get optimum physical quality with the Simplex Lattice Design method. The optimum formula of chrysanthemum flower ethanol extract lotion does not have good physical quality stability based on the parameters of adhesion, dispersion, pH and viscosity during 30-day storage. The lotion irritation test results obtained an irritation index of 0, so it can be concluded that the optimum formula of chrysanthemum extract lotion extract does not cause skin irritation and is quite acceptable to probandus.
Potential of Essential Oil as Anti-Dandruff in Scalp Treatment Preparations Detria Wulandari; Iyan Sopyan; Rifkarosita Putri Ginaris; Muhammad Faizal Fathurrohim; Ira Maya
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5600

Abstract

Most scalp problems in the community are dandruff. The most widely known microorganism that contributes to dandruff is Malassezia spp. The currently available treatment options for anti-dandruff are mostly synthetic substances. Unfortunately, these synthetic substances can cause various problems, such as side effects and drug resistance, especially the compliance of the patient. Herbal remedies that can be used to reduce the risks are essential oils. There are several essential oils that have been researched on anti-dandruff potential are Tea Tree, Lemongrass, Lavender, Rosemary, Eucalyptus, Coleus amboinicus, etc. The potential of essential oils as anti-dandruff ingredients in scalp remedies will be discussed in this article review. This article review was conducted using a comparative research method from a variety of sources, including online research journals and other sources. The outcome of this review article revealed that the previously mentioned essential oils have positive results in inhibiting the growth of the Malassezia sp., in its pure form, a combination of pure essential oils, or when in product form.
The Effectiveness of Flavonoids in Pigeon Pea (Cajanus cajan) as Inhibitors of α-Glucosidase Enzyme in Anti-diabetes Ginaris, Rifkarosita Putri; Fauzah, Na’imatul Retno
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.9311

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia, due to relative and absolute insulin deficiency of the body. Acarbose is a drug that can be used to treat diabetes mellitus, especially type II diabetes mellitus. Type II diabetes mellitus is an endocrine disease that causes 95 % of deaths worldwide. Gude bean extract (Cajanus cajan) is one alternative to the use of natural anti-diabetic medicine, containing saponins, flavonoids, phenolics, and tannins. Flavonoids are antioxidant compounds that have a hypoglycemia effect in people with diabetes mellitus. This study aimed to test the inhibitory activity of alpha-glucosidase enzyme from gude bean extract. The enzyme α-glucosidase activity was quantified by measuring the quantity of para-nitrophenol generated at a wavelength of 405 nm. The inhibitory power of the α-glucosidase enzyme was seen from the IC50 value. Gude Bean Extract has the ability to inhibit the enzyme α-glucosidase resulting in an IC50 value of 69.67 ppm strong level activity. Gude Bean Extract has the ability to inhibit the enzyme α-glucosidase resulting in an IC50 value of 69.67 ppm with a strong strength level
Penyuluhan Mutu Produk Permen Jelly Sereh Wangi Menurunkan Kadar Gula Darah, Tawangmangu Putri Ginaris, Rifkarosita; W, Fitria Eka Resti; Nurrahman, Alfina; Setyawan, Irfan Bagus
ABDIMASKU : JURNAL PENGABDIAN MASYARAKAT Vol 8, No 1 (2025): JANUARI 2025
Publisher : LPPM UNIVERSITAS DIAN NUSWANTORO

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus adalah penyakit metabolik yang ditandai dengan hiperglikemia, karena kekurangan insulin relatif dan absolut tubuh. Kandungan Sereh Wangi (Cymbopogon nardus (L.) Rendle) mengandung senyawa flavonoid, senyawa fenolik, terpenoid dan minyak esensial sebagai anti diabetes. Alternatif camilan bagi penderita DM yaitu dalam bentuk produk permen jelly sereh wangi dengan menggunakan madu sebagai pemanis. Permasalahan utama yang dihadapi oleh usaha pembuatan permen jelly untuk mengembangkan usahanya adalah kurangnya inovasi dari segi packaging dan keterbatasan pemasaran produk permen jelly. Tujuan kegiatan ini adalah memberikan informasi dan meningkatkan pengetahuan kepada Ibu-ibu Kader PKK desa Bandardawung terkait khasiat daun sereh wangi, cara pembuatan permen jelly sereh wangi, dan mutu pengemasannya. Metode yang digunakan penyuluhan kepada ibu-ibu kader PKK desa Bandardawung, Tawangmangu dan pre test/post test dalam bentuk kuesioner. Instrumen yang digunakan adalah power point, lealflet dan kuesioner. Dalam pelaksanaan kegiatan ini terbagi menjadi tiga tahapan, yaitu pra kegiatan, proses kegiatan, dan evaluasi. Hasil kegiatan penyuluhan ini menunjukkan bahwa presentase keaktifan peserta mencapai 76% dan adanya nilai post test mencapai 89%, dengan respon peseta 79% baik sekali.
Potensi Aktivitas Antioksidan Pada Tanaman Obat Yang Dihasilkan Oleh Mikroba Endofit Sebagai Potensi Rekayasa Genetika Molekuler Melalui Gen Editing (Kajian Pustaka) Tri Pamungkas, Barolym; Rezaldi, Firman; Suminar, Erni; Putri Ginaris, Rifkarosita; Trisnawati, Desi
JAGO TOLIS : Jurnal Agrokompleks Tolis Vol 5 No 2 (2025): Mei
Publisher : Universitas Madako Tolitoli

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56630/jago.v5i2.754

Abstract

Pencarian senyawa metabolit sekunder yang berhasiat sebagai sumber antioksidan jangka panjang dapat dihasilkan melalui metode bioteknologi yang cukup sederhana hingga modern baik dengan menggunakan kemampuan mikroba endofit sampai penggunaan teknik rekayasa genetika molekuler yang saat ini cukup populer yaitu gen editing. Jaringan tanaman yang berpotensi dalam menghasilkan mikroba endofit meliputi bunga, buah, batang, daun, akar, dan biji yang berperan penting dalam memproteksi tanaman inang dari cekaman lingkungan dan mikroorganisme pesaing. Salah satu jenis jamur mikro yaitu Muscodor albus telah terbukti mampu memproduksi campuran senyawa organik volatil dari tanaman kayu manis. Senyawa organik volatil tersebut memiliki aktivitas farmakologi sebagai sumber antimikroba dalam spektrum luas. Taxomyces andreane merupakan salah satu kapang endofit yang diproduksi dari tanaman Paclitaxel dan berpotensi dalam menghasilkan senyawa taksol yang memiliki aktivitas farmakologi sebagai sumber antikanker. Pestalotiopsis microspore merupakan salah satu kultur mikroba penghasil senyawa pestacin dan isopestacin dari tanaman Ketapang dan berfungsi sebagai sumber antioksidan maupun antikanker. Antioksidan digolongkan menjadi antioksidan endogen antioksidan enzim dan vitamin. Rekayasa genetika dengan memanfaatkan Agrobacterium tumafaciens berpotensi dalam menghasilkan sifat yang dibutuhkan atau diinginkan sesuai target melalui penyisipan gen dari organisme yang berperan sebagai pendonor gen menuju organisme penerima gen. Gen lancolate merupakan salah satu gen yang berhasil disisipkan untuk mengkode daun tomat dan merubah daun majemuk dalam kondisi besar menjadi lebih kecil. Metode gen editing yang direkomendasikan berupa CRISPR-Cas 9 karena dapat menyunting gen lancolate pada buah tomat dengan urutan genom diploid yang jelas.
Penguatan Konsep Berbasis Pertanian Berkelanjutan di Negara India sebagai Solusi Mengurangi Efek Gas Rumah Kaca (Literature Review) Yudianto, Tri; Pramono, Edi; Rezaldi, Firman; Rahmad, Sukardi Sugeng; Yenny, Ratna Fitry; Gumilar, Roni; Trisnawati, Desi; Ginaris, Rifkarosita Putri; Suminar, Erni
Jurnal Agroteknologi (Agronu) Vol 4 No 01 (2025): Jurnal Agroteknologi (Agronu)
Publisher : Universitas Ma'arif Nahdlatul Ulama Kebumen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53863/agronu.v4i01.1521

Abstract

The conventional agricultural system that is applied tends to use chemicals such as pesticides, on the one hand, providing various positive impacts, including increasing productivity quickly, meeting food needs efficiently, and helping food insecurity as often occurs in India. Sustainable agricultural systems are aimed at reducing environmental damage, maintaining agricultural productivity, increasing farmers' income and improving the stability and quality of life of rural communities. Three big indicators that can be seen are that the environment is sustainable, the economy is improving (prosperous), and it is socially accepted by the farming community. Other negative impacts on conventional agricultural systems include decreasing soil quality, giving rise to new pests and diseases, environmentally friendly microorganisms becoming extinct, toxic chemicals threatening the condition of the biosphere in the food chain. The concept of organic farming that is applied ideally is based on optimal, balanced, efficient management of land, water and land, so that existing biodiversity is one of the external efforts to provide a positive impact. In writing this literature review, the sections that will be discussed include the application of conventional agricultural systems that occur in India, suggestions and improvements that can be implemented based on potential such as modeling greenhouse gas emissions from agriculture, GHG (Greenhouse Gas) mitigation from agriculture, absorption of element C in agricultural soil, conservation agriculture, reducing nitrous oxide emissions, economic implications of greenhouse gas mitigation, and the use of butterfly pea flower kombucha in agricultural aspects
Penyuluhan Cara Konsumsi Kombucha Bunga Telang Sebagai Minuman Probiotik Bagi Pasien Kolesterol bagi Masyarakat Kampung Pekuncen Cilegon Banten Firman Rezaldi; Sukardi Sugeng Rahmad; Rifkarosita Putri Ginaris; Wijayanti Wijayanti; Desi Trisnawati; M. Fariz Fadillah; Ucu Wandi Somantri; Heny Sasmita
Jurnal Relawan dan Pengabdian Masyarakat REDI Vol. 2 No. 2 (2024): November
Publisher : Yayasan REDI Tiga Monas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69773/mkxfx787

Abstract

Peningkatan jumlah Low Densitas Lipoprotein (LDL), trigliserida, dan High Densitas Lipoprotein (HDL) yang cenderung mengalami penurunan dikenal sebagai kolesterol tinggi atau hiperkolesteromia. Pengobatan kolesterol secara umumnya dilakukan melalui terapi secara kimiawi yang telah memiliki aktivitas farmakologi sebagai penurun kolesterol yaitu simfastatin. Efek samping dari pengobatan secara kimiawi adalah terjadinya infalamasi pada lambung, kerusakan hati, ginjal, dan resistensi semakin meningkat. Solusi yang ditawarkan dalam meminimalisir pengobatan kolesterol secara kimiawi yaitu dengan pemanfaatan kombucha bunga telang sebagai minuman probiotik yang telah terbukti dapat diperankan sebagai substansi pangan fungsional, obat, dan kosmetik, sehingga ketaatan dalam mengkonsumsi kombucha bunga merupakan salah satu indikator keberhasilan dalam menurunkan kadar kolesterol. Pengabdian ini bertujuan untuk mengetahui level kepatuhan masyarakat dalam mengkonsumsi kombucha bunga telang dalam upaya menurunkan kolesterol.  Metode pengabdian ini dilakukan secara deskriptif dan teknik pengambilan sampel dilakukan dengan cara purposive sampling. Hasil pengabdian ini telah membuktikan bahwa ketaatan masyarakat dalam level tinggi mencapai 24,40%, sedang 68,30%, rendah 7,33 % sehingga dapat disimpulkan masyarakat yang memiliki kolesterol tinggi dikampung pekuncen desa ciwedus kota cilegon provinsi banten mempunyai tingkat ketaatan yang sedang dengan prosentase sebesar 68,30%.
COMPARISON OF VITAMIN C EXTRACTION FROM YELLOW AND ORANGE PAPRICA USING ETHANOL AND METANOL SOLVENTS Yanti, Jamilah Hamidi; Ginaris, Rifkarosita Putri; Nurrahman, Alfina
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 2 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i2.2848

Abstract

Paprika mengandung jumlah vitamin C yang signifikan, paprika dikenal karena khasiatnya yang sangat bermanfaat bagi kesehatan, termasuk kemampuannya untuk menangkal radikal bebas dan bertindak sebagai antioksidan bagi tubuh. Studi ini menggunakan pelarut etanol dan metanol untuk mengukur kandungan vitamin C pada  paprika oranye dan kuning. Penelitian ini dilakukan di Laboratorium Kimia Universitas Trunojoyo Madura pada Januari 2025. Menggunakan etanol dan metanol sebagai pelarut, prosedur maserasi digunakan untuk mengekstrak paprika. Panjang gelombang maksimum juga ditentukan. Pemeriksaan sampel ini menunjukkan ymax sebesar 373,5 nm. Persamaan y = 0,0006 x + 0,019 menunjukkan linearitas. Analisis kuantitatif dilakukan pada rentang panjang gelombang 250–400 nm menggunakan spektrofotometri UV-Vis. Pelarut etanol menghasilkan 340 mg/100 g vitamin C pada paprika kuning, sedangkan pelarut metanol menghasilkan 562,5 mg/100 g. Pelarut etanol menghasilkan 215 mg/100 g vitamin C dari paprika oranye, sedangkan pelarut metanol menghasilkan 562,5 mg/100 g. Hasil uji desain blok kelompok acak lengkap dengan y = 0,05 menunjukkan perbedaan yang signifikan dalam jumlah vitamin C yang terdapat pada setiap sampel.
Potential of Hanjeli (Coix lacryma-jobi) as an antifungal Microsporum Gypseum Causes Skin Infections: Extract, Boiled Water, Kombucha, and Bath Soap Haryani, Tri Saptari; Nurfajriah, Mutiara Siti; Sudrajat, Cecep; Rezaldi, Firman; Yudianto, Tri; Ginaris, Rifkarosita Putri; Rahmad, Sukardi Sugeng
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.11744

Abstract

Job's tears (Coix lacryma-Jobi L.) are known to contain chemical compounds of the alkaloid, flavonoid and tannin groups that have the potential as antifungals. Microsporum gypseum is one of the dermatophyte fungi that causes dermatitis, a disease that infects skin of both animals and humans. The study aims to test the activity and determine optimal concentration of Job's tears seed extract, Job's tears seed boiled water, Job's tears leaf kombucha, and Job's tears seed extract bath soap formulation as antifungals against Microsporum gypseum which causes skin disease infections. The research method used agar diffusion with the well technique (Agar Well Diffusion), the research parameters included phytochemical tests of the extract, measuring diameter inhibition area. The results phytochemical test obtained alkaloid compounds, and results of activity test of the Job's tears seed extract formulation, Job's tears seed boiled water, Job's tears leaf kombucha, and Job's tears seed extract bath soap obtained optimal diameter of the inhibition area overall at an extract concentration of 40%. Conclusion,  activity of ethanol extract of hanjeli seeds, boiled water of hanjeli seeds, hanjeli leaf kombucha, and hanjeli seed extract bath soap at a concentration of 40% have antifungal activity against Microsporum gypseum which causes skin diseases.
Evaluasi Penggunaan Obat Anti diabetes Oral pada Pasien Diabetes Melitus Tipe II di Instalasi Rawat Jalan Rumah Sakit Azizah Metro Pamungkas, Pratiwi May; Ginaris , Rifkarosita Putri; Nurrahman, Alfina
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.90

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood glucose levels (hyperglycemia). This condition arises due to impaired insulin production, the body's inability to effectively utilize insulin, or a combination of both. The rational use of antidiabetic drugs is crucial in managing blood glucose levels in diabetic patients. This study aimed to evaluate the use of oral antidiabetic drugs in patients with type 2 DM at the outpatient clinic of Azizah Metro Hospital. The research employed a descriptive design with retrospective data collection, using patient medical records from October to December 2024 as the data source. The sampling technique was total sampling, with a total of 80 patients as respondents. The majority of patients were female (77.5%), and the most prevalent age group was 56–65 years (48.75%). Most patients were on monotherapy (68.75%), with glimepiride being the most frequently prescribed drug (33.75%). The evaluation results showed that all patients (100%) met the criteria for appropriate drug use based on patient condition, indication, drug type, and dosage. In conclusion, the use of oral antidiabetic drugs in type 2 DM outpatients at Azizah Metro Hospital during the period of October–December 2024 has met the principles of rational therapy with an accuracy rate of 100%.
Co-Authors Alfina Nurrahman Alfina Nurrahman Amalia Eka Putri Andri Tri Cahyono Arti Wahyu Utami Arti Wahyu Utami Arti Wahyu Utami Bramantyo Cahyono, Andri Tri Dea Nurfadhillah Desi Trisnawati Detria Wulandari Dwi Wahyuni Dyah Rohma Wati Edi Pramono Eman eman Erni Suminar Esa Aji Pratama Faizah, Nai’matul Retno Faizah, Na’imatul Retno Fatchani, Sathi Fatikha, Zulfania Shandra Fauzah, Na’imatul Retno Fitria Eka Resti Wijayanti Gumilar, Roni Hariningsih, Yetti Heny Sasmita Ira Maya Irfan Bagus Setyawan Istikhomah, Rekha Aulia Iyan Sopyan Jihan Nabilla Kurniawan, Maskun Kustyarini, Farida M. Fariz Fadillah Misbakhul Munir Mu'jijah, Mu'jijah Muhammad Faizal Fathurrohim Nabilla, Jihan Na’imatul Retno Faizah Novi Ayuwardani Nurahman, Alfina Nurfajriah, Mutiara Siti Nurrahman, Alfina Oentari, Octavina Dyah Pamungkas, Barolym Tri Pamungkas, Pratiwi May Pratiwi, Reza Safinda Pujiastuti, Nanik Purbanova, Reni Putri, Desvita Maharani Rahmad, Sukardi Sugeng Ratna Fitry Yenny Rekha Aulia Istikhomah Rekha Aulia Istikhomah Reni Purbanova Resti Wijayanti, Fitria Eka Rohmatulloh, Rizal Sadida, El Santi Saifullah, Ipul Sari, Sinta Wisma Sasmita, Heny Setiawati, Puput Setyawan, Irfan Bagus Sinta Wisma Sari Sitanggang, Andrianus Bilhot Sudrajat, Cecep Sugiono Sugiono Sukardi Sugeng Rahmad Sukardi Sugeng Rahmad TN Saifullah Sulaiman Tri Saptari Haryani Tri Yudianto Trisnawati, Desi Ucu Wandi Somantri Ucu Wandi Somantri Usman Setiawan Vevi Maritha W, Fitria Eka Resti Widyaningsih, Ragil Wijayanti Wijayanti Wijayanti, Fitria Eka Resti Yanti, Jamilah Hamidi Yenny, Ratna Fitry Yudianto, Tri Yuliana Kolo Zulananta, Shohihunnatiq