<![CDATA[Moringa leaves (Moringa oleifera L.) have gastroprotective activity, making them suitable for use in floating tablets to prolong the residence time of drugs in the stomach. Floating tablets typically use xanthan gum and hydroxypropyl methylcellulose (HPMC) polymers as drug release matrices. This study aims to evaluate the physical properties of floating tablets made from ethanol extract of moringa leaves with a combination of xanthan gum and HPMC, as well as to determine the appropriate polymer concentration. Experimental studies were conducted with three formulas: F1 (15% xanthan gum; 5% HPMC), F2 (10% xanthan gum; 10% HPMC), and F3 (5% xanthan gum; 15% HPMC), using the wet granulation method. The physical properties of the granules were evaluated by testing the flow rate, Carr index, and Hausner ratio, then molded into 750 mg tablets and evaluated for physical properties (n = 3), including organoleptic properties, weight uniformity, size, hardness, friability, and floating test in 0.1 N HCl medium (pH 1.2; 37 ± 0.5 °C). The results showed that all formulations did not meet the weight uniformity and friability test (> 1%). Size uniformity and hardness (4–8 kg) met the requirements. The floating test showed that no formula was able to float for up to 30 minutes (floating lag time > 30 minutes; floating time = 0 minutes). It was concluded that the combination of xanthan gum and HPMC in the range of 5–15% did not produce moringa leaf extract floating tablets that met the physical parameters and floating test.]]>
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