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All Journal Pharmascience Acta Pharmaciae Indonesia : Acta Pharm Indo Chemistry Indonesian Journal of Chemical Research JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Mandala Pharmacon Indonesia Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Pena Medika : Jurnal Kesehatan Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Buana Farma INTERNATIONAL JOURNAL OF EDUCATION, INFORMATION TECHNOLOGY, AND OTHERS Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Sosial dan Sains Pharmacy Genius SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT Jurnal Keperawatan dan Kesehatan (JKK) Kartika : Jurnal Ilmiah Farmasi
Nawangsari, Desy
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Evaluation of the physical properties of andaliman (Zanthoxylum acanthopodium DC) fruit extract tablets using polyvinylpyrrolidone as a binder agent Turnip, Monika Maristella; Sunarti, Sunarti; Nawangsari, Desy
Acta Pharmaciae Indonesia Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.6900

Abstract

Background: Zanthoxylum acanthopodium DC, also known as andaliman, is a traditional herb utilized predominantly as a spice. It is rich in bioactive compounds such as alkaloids, flavonoids, tannins, saponins, and terpenoids, which exhibit analgesic activities. Objective: This study aims to develop a tablet formulation of andaliman fruit extract, employing polyvinyl pyrrolidone (PVP) K-30 as a binder, utilizing the wet granulation method. Method: The andaliman fruit was processed to extract its components using 96% ethanol. The extract, at a concentration of 100 mg, was then formulated into three different tablet formulations, varying in PVP K-30 concentration: F1 (1%), F2 (3%), and F3 (5%). These formulations were analyzed for granule characteristics and physical properties of the tablets. Results: Granule testing confirmed that all formulations met the requirements for quality granules. Among the formulations, F1 (1% PVP concentration) demonstrated superior physical properties: size uniformity of 1.22±0.00 cm, weight uniformity of 518.53±10.15 mg, friability of 0.45±0.01%, hardness of 6.34±0.05 kg, and disintegration time of 9.42±0.90 minutes. Conclusion: The tablet formulation of Andaliman fruit extract with 1% PVP K-30 exhibited the most favorable physical properties, suggesting its potential viability for further development and testing. This study lays the groundwork for exploring Andaliman fruit-based analgesic tablets.
Formulation of Scrub Preparations With Variations in the Concentration of Seagrass Leaf Ethanol Extract (Enhalus acoroides) Inayah, Somatul; Prabandari, Rani; Sunarti, Sunarti; Nawangsari, Desy
International Journal of Education, Information Technology, and Others Vol 7 No 2 (2024): International Journal of Education, information technology   and others (IJEIT)
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.10968299

Abstract

Seagrass leaves (Enhalus acoroides) are known to contain antioxidants that can protect the skin from free radicals and keep the skin's pH stable. Group compounds found in seagrass leaf components are fernolics, tannins, flavonoids, and glycosides. To facilitate the application of seagrass leaf extract, it is necessary to formulate one of them, namely scrub preparations. Seagrass leaf ethanol extract formulation uses variations in concentrations of F1 20%, F2 30% and F3 40%. The purpose of the study was to determine physical properties tests, irritation tests and moisture tests on seagrass leaf ethanol extract scrub preparations. Seagrass leaf extract was extracted by remaceration method using 70% ethanol then formulated into scrub preparations. Scrub is a liquid or semisolid preparation in the form of an emulsion. The results of the physical properties test of scrub preparations showed semisolid preparations of green to dark green color, had a characteristic seagrass odor and were homogeneous because they did not show the presence of coarse grains. F1 viscosity results 39,260, F2 results 39,278, F3 results 39,385, dispersion tests obtained F1 7.93, F2 results 8 and F3 results 7.73, then F1 adhesion test results 5.63, F2 results 5.75, F3 results 7.14 and F1 pH test results of 5.7, F2 results 5.6 and F3 5.6. In the irritation test results, the three formulas showed no irritation and the moisture test of the three formulas was less moist. It can be concluded that the results of the physical properties test of viscosity, pH, adhesion and dispersion tests are in accordance with the range required, the irritation test in the three formulas does not occur irritation and in the moisture test the results obtained are moist.
Solid Dispersion of Acetosal Using Polyvinyl Pyrrolidone (PVP) K-30 in Tablets with Direct Compressing Method Khasanah, Khuswatun; Nawangsari, Desy; Kusuma, Ikhwan Yuda
Indonesian Journal of Chemical Research Vol 10 No 3 (2023): Edition for January 2023
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2023.10-kha

Abstract

Acetosal is classified in the Biopharmaceutical Classification System (BCS) class II (low solubility, high permeability). Low solubility causes a decreased dissolution rate. Polyvinyl pyrrolidone (PVP) K-30 is an inert carrier easily soluble in water and can influence the solubility of a drug substance. Efforts to increase the solubility of acetosal make a solid dispersion system. This study aims to determine the effect of the solid dispersion system of acetosal: PVP K-30 on dissolution rate, the ratio of the solid dispersion with the best dissolution rate, and the physical properties of acetosal tablets formed in the dispersion system. Solid dispersions using the dissolving method with variations in the concentration of acetosal: PVP K-30 1:1, 1:3, and 1:5. The results of the dissolution test of acetosal in solid dispersion powder, i.e., PVP Formula 1:5, which has the highest dissolution percentage compared to formula 1:1 and 1:3 with the concentration this formula was 140.96 mg, dissolution percentage was 28.19±0,63% in 30 minutes. Statistical results by ANOVA test show a significant difference of 0.044 (p<0.05). The physical properties of tablets with a dispersion system show higher addition of PVP K-30. This result is related to slower disintegration time and lower friability.
FORMULASI DAN UJI STABILITAS FISIK SEDIAAN FACIAL WASH EKSTRAK ETANOL DAUN MATOA (Pometia Pinnata J.R & G. Forst.) Dzakiyyatunnisa, Hanifah; Nawangsari, Desy; Samodra, Galih
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1185

Abstract

Kulit wajah adalah bagian tubuh yang selalu terpapar debu, polusi, sinar ultraviolet, radikal bebas bahkan seringkali sisa sisa riasan jika tidak dibersihkan dengan baik. Oleh karena itu, kulit wajah harus mendapat perhatian ekstra agar tetap terjaga dengan baik. Perawatan wajah awal bisa dilakukan secara rutin dengan menggunakan pembersih wajah. Namun banyak pembersih wajah yang mengandung bahan kimia sintetis seperti triclosan yang dapat menyebabkan disfungsi tiroid. Untuk mengatasinya, Anda bisa menggunakan bahan alami seperti daun matoa. Ekstrak etanol daun matoa mempunyai efek antibakteri terhadap bakteri staphylococcus aureus. Tujuan penelitian ini untuk mengetahui formula facial wash ekstrak etanol daun matoa dengan uji sifat fisik dan stabilitas sediaan, untuk mengetahui respon iritasi sediaan dan untuk mengetahui kesukaan responden. Metode penelitian ini yaitu eksperimental laboratorium. Hasil pengujian organoleptik dan homogenitas didapatkan hasil yaitu tidak ada perbedaan pada formula kecuali warna pada F3 lebih coklat tua. Pengujian pH didapatkan hasil tidak memenuhi standar pH. Berdasarkan pengujian statistik diketahui bahwa viskositas mendapatkan nilai p value <0,05 yang berarti terdapat perbedaan yang signifikan dengan penggunaan konsentrasi ekstrak etanol daun matoa. Pada hasil uji stabilitas, nilai pH pada ketiga formula tidak mempunyai pengaruh yang signifikan, nilai daya sebar F3 mempunyai pengaruh yang signifikan, nilai daya busa pada F1 mempunyai pengaruh yang signifikan, nilai viskositas pada ketiga formula mempunyai pengaruh yang signifikan. Hasil uji hedonik menunjukkan F1 mendapatkan rangking kesukaan pertama dengan persentase 33,90 %.
PERBANDINGAN SUHU DAN KECEPATAN PENGADUKAN PADA PREGELATINASI TERHADAP KARAKTERISTIK PATI TALAS PRATAMA (Colocasia esculenta (L). Schott var. Pratama) Firdaus, Anisa Kautsar; Nawangsari, Desy; Febrina, Dina
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1190

Abstract

Indonesia termasuk dalam zona wilayah tropis yang mempunyai banyak tanaman sebagai bahan eksipien tablet yaitu pati talas pratama (Colocasia esculenta (L). Schott var. Pratama). Pada industri farmasi, penggunaan pati alam sangat terbatas dikarenakan pati alam mempunyai sifat alir dan kompresibilitas yang buruk sehingga banyak dilakukan modifikasi untuk mengatasi hal tersebut salah satunya yaitu dengan modifikasi pati alam menggunakan metode pregelatinasi sehingga sifat alir dan kompresibilitas dapat menjadi lebih baik. Penelitian ini bertujuan untuk mengevaluasi pengaruh suhu dan kecepatan pengadukan terhadap karakteristik pati talas pratama yang telah dimodifikasi secara pregelatinasi. Penelitian ini dilakukan dengan eksperimen laboratorium menggunakan pati alami sebagai kontrol serta enam perlakuan modifikasi pati pregelatinasi, dimana 3 perlakuan menggunakan suhu 45 °C dengan kecepatan pengadukan 200, 250, dan 300 rpm dan 3 perlakuan menggunakan suhu 65 °C dengan kecepatan 200, 250, dan 300 rpm. Hasil penelitian menunjukkan pati alami dan pati pregelatinasi bertekstur serbuk halus berwarna putih kecoklatan, tidak berasa dan tidak berbau, pH pati alami dan pati pregelatinasi berada pada rentang 4,5-7,0, susut pengeringan semua pati berada pada <15%. Hasil uji laju alir pati alami dan pati pregelatinasi tidak dapat mengalir pada granul flow tester, tetapi sudut istirahat pati alami dan pati pregelatinasi telah memenuhi persyaratan yaitu ≤30°. Kompresibilitas yang tidak memenuhi persyaratan dengan kelembaban air yang tinggi yaitu pati alami, P1 dan P2. Hasil analisis statistik menggunakan One way ANOVA dan Post Hoc menghasilkan hasil pati pregelatinasi yang baik dengan peningkatan suhu dan kecepatan pengadukan, hasil terbaik pada pati pregelatinasi dengan perlakuan 65 °C dan 300 rpm.
OBAT KUMUR EKSTRAK ETANOL KULIT BATANG KAYU MANIS (CINNAMOMUM VERUM J.PRESL) SEBAGAI PENGHAMBATAN PERTUMBUHAN BAKTERI STREPTOCOCCUS MUTANS Umayah, Dani Yatul; Nawangsari, Desy; Fitriana, Adita Silvia
Jurnal Keperawatan dan Kesehatan Vol 15 No 2 (2024): Jurnal Keperawatan dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Keperawatan Muhammadiyah Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54630/jk2.v15i2.380

Abstract

Bad breath is caused by volatile sulfur compounds (VSCs) produced by the anaerobic bacteria Streptococcus mutans through the decomposition of food waste. This problem can be overcome with antibacterial mouthwash. Cinnamon contains essential oils, phenols, flavonoids, saponins and terpenoids, which have antibacterial properties. This study aimed to formulate a mouthwash from ethanol extract of cinnamon and evaluate its physical properties, stability, and inhibitory power against Streptococcus mutans using the Kirby-Bauer method. This research was experimental by making mouthwash using cinnamon extract with concentrations of 10% (FI), 12.5% ​​(FII), and 15% (FIII). The results of the research showed that the mouthwash preparations were brick red in color with different intensities, all preparations were homogeneous, had a pH according to standards except for FII and all preparations did not meet the required viscosity values. The stability test showed that the preparation was stable in storage except for the viscosity parameter FIII. The results of the antibacterial activity test showed that the inhibitory power of FI, FII, FIII against Streptococcus mutans bacteria was 7.33 mm, 8.50 mm, 9.33 mm respectively. The inhibitory power of FII and FIII was better than the positive control, namely total care-antibacterial mouthwash (8.33 mm).
Pelatihan Pembuatan Lilin Aromaterapi Antinyamuk Pada Anggota Fatayat Nu Ranting Purwosari Nawangsari, Desy; Kurniasih, Khamdiyah Indah; Prabandari, Rani; Fitri, Ely Nurul
Kolaborasi: Jurnal Pengabdian Masyarakat Vol 5 No 2 (2025): Kolaborasi: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/kolaborasi.v5i2.484

Abstract

Introduction: Used cooking oil is oil that has been used repeatedly up to 3-4 times frying. The negative impact of used cooking oil if thrown away will become waste and damage the surrounding environment. One of the products of used cooking oil processing is aromatherapy candles and soap. Various forms of aromatherapy have sprung up such as essential oils, candles, incense, soaps and massage oils. People only use candles as a source of lighting when there is no electricity source. The function of candles is not only a lighting aid but is widely used as a room decorator and as a room fragrance, in this case what is commonly used is aromatherapy candles. Objective: The objectives of this activity are (1) Minimizing the disposal of used cooking oil (2) Changing the lifestyle of the community to process used cooking oil waste based on zero waste industry (3) Reducing the disposal of used cooking oil in any place can reduce the risk of groundwater pollution (4) Creating anti-mosquito aromatherapy candle products that have economic value. Method: The method of implementing the activity was carried out by providing material on the utilization of used cooking oil and training in making aromatherapy candle products for mosquitoes. Result: The outputs of this activity are increased knowledge related to products and the risk of contamination to the environment, increased knowledge and skills of partners in making aromatherapy candles. Conclusion: The training on making mosquito-repellent aromatherapy candles from used cooking oil successfully improved participants' knowledge and skills. It supports waste reduction and economic empowerment. Despite challenges in raw material consistency, the program holds potential for sustainability and commercialization.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Alpukat (Persea americana Mill) terhadap Pertumbuhan Bakteri Streptococcus mutans Rachmawati, Ira; Samodra, Galih; Nawangsari, Desy
Jurnal Pharmascience Vol 12, No 1 (2025): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i1.20260

Abstract

Kesehatan gigi dan mulut ialah bagian penting dari kesehatan keseluruhan dan dapat mempengaruhi kualitas hidup. Kurangnya perawatan gigi dapat menyebabkan karies , penyakit yang umumnya disebabkan oleh Streptococcus mutans. Bakteri ini memainkan peran utama dalam pembentukan karies gigi karena kemampuannya memproduksi asam melalui fermentasi karbohidrat yang mengakibatkan demineralisasi enamel gigi.  Daun alpukat yang mengandung alkaloid, flavonoid, saponin, dan tanin, memiliki potensi sebagai bahan alami dengan aktivitas antibakteri. Penelitian ini bertujuan untuk mengetahui ekstrak daun alpukat dalam menghambat pertumbuhan Streptococcus mutans dengan konsentrasi 25%, 50%, dan 75% menggunakan metode sumuran. Hasil uji antibakteri menunjukkan bahwa ekstrak daun alpukat menghambat bakteri konsentrasi 25% dengan rata-rata zona hambat sebesar 9,11 mm (respon hambatan sedang), konsentrasi 50% dengan rata rata zona hambat 8,11 mm (respon hambatan sedang), konsentrasi 75% dengan rata rata 10,81 mm (respon hambatan kuat). Pada konsentrasi 50% mengalami penurunan diameter zona hambat. Hal ini kemungkinan disebabkan karena konsentrasi 50% tidak meresap secara sempurna ke dalam paper diam dan sulit berdifusi dalam media sehingga daya hambat yang terbentuk lebih kecil dari pada konsentrasi 25%. Berdasarkan uji One Way ANOVA, nilai signifikansi 0,000 (<0,05) menunjukkan perbedaan signifikan antara berbagai konsentrasi ekstrak dalam menghambat Streptococcus mutans. Kesimpulannya, ekstrak etanol daun alpukat efektif sebagai antibakteri terhadap Streptococcus mutans. Kata Kunci: Kesehatan Gigi, Ekstrak Daun Alpukat, Zona Hambat, Streptococcus mutans Dental and oral health is an important part of overall health and can affect quality of life. The lack of dental care can lead to caries, a disease commonly caused by Streptococcus mutans. This bacterium plays a major role in the development of dental caries due to its ability to produce acid through carbohydrate fermentation, resulting in enamel demineralization. Avocado leaves, which contain alkaloids, flavonoids, saponins and tannins, have potential as a natural ingredient with antibacterial activity. This research aims to determine whether avocado leaf extract inhibits the growth of Streptococcus mutans with concentrations of 25%, 50% and 75% using the well method. The antibacterial test results showed that avocado leaf extract inhibited bacteria at a concentration of 25% with an average inhibitory zone of 9.11 mm (medium inhibitory response), a concentration of 50% with an average inhibitory zone of 8.11 mm (medium inhibitory response), a concentration of 75 % with an average of 10.81 mm (strong resistance response). Based on the One Way ANOVA test, a significance value of 0.000 (<0.05) indicates a significant difference between various extract concentrations in inhibiting Streptococcus mutans. In conclusion, ethanol extract of avocado leaves is effective as an antibacterial against Streptococcus mutans. 
AKTIVITAS EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) PADA SEDIAAN SALEP BASIS ABSORPSI TERHADAP BAKTERI Propionibacterium acne Maulana, Restu; Prabandari, Rani; Nawangsari, Desy
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p65-77

Abstract

Moringa leaves contain flavonoids, alkaloids, saponins and tannins that can inhibit bacterial growth. In order to make the use of moringa leaves more practical, an absorption base ointment formulation was made. Ointment preparations were chosen because they are suitable for medicinal purposes on the skin because the drug contact with the skin is longer. This study aims to determine the physical properties, stability and antibacterial activity of absorption base ointment preparations of moringa leaf ethanol extract. The research method is experimental laboratory. The extract concentrations used were F0 (base), F1 (15%), F2 (20%) and F3 (25%). Physical quality testing is seen from organoleptic, homogeneity, pH, spreadability and stickiness. The pH test results were sequentially obtained as 6.33 ± 0.15, 5.9 ± 0.1, 5.6 ± 0.1 and 5.56 ± 0.15. The spreadability test sequentially obtained 2.87 ± 0.07, 2.9 ± 0.05, 3.05 ± 0.05 and 3.25 ± 0.1 cm. The stickiness test was 17.60 ± 0.60, 17.59 ± 0.46, 16.87 ± 0.47 and 16.18 ± 0.56 seconds. The results were analyzed using SPSS 26 with One Way ANOVA, there were significant differences in pH values, spreadability and adhesiveness with a significance value of <0.05. The results of the stability test with the Cycling test method analyzed by T-test there was no significant difference from each formula between day 0 and day 12 with a 2-tailed value >0.05 which means that the formulas made are all stable in the stability test. Formula 1, 2 and 3 can inhibit Propionibacterium acne bacteria with an average inhibition zone of F1 10.34 ± 1.86 mm, F2 13.77 ± 3.43 mm and F3 16.67 ± 0.97 mm. It can be concluded that the three formulas have strong inhibition.
KARAKTERISASI MASSA CETAK DAN TABLET VITAMIN C DENGAN KOMBINASI PATI PREGELATINASI UMBI TALAS PRATAMA DAN AVICEL PH 102 SEBAGAI FILLER-BINDER Fitriyani, Gita; Nawangsari, Desy; Fauziah
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 3 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i3.806

Abstract

Making vitamin C tablets using felt directly because this material is very sensitive to heat.. However, direct felting is difficult to do due to the poor flow of vitamin C, so it is necessary to add excipients such as starch and Avicel PH 102. This study aims to evaluate vitamin C tablets with a combination of pregelatinized starch of primary taro tubers and Avicel PH 102 as a filler-binder. The study was conducted in a laboratory experiment with five different formulas: F1 (1:0), F2 (0:1), F3 (1:1), F4 (1:3), and F5 (3:1). Flow rate results F2, F3, F4, and F5 are eligible, while F1 is not. All formulas meet the requirements of break angle, uniformity of weight, size, and crushing time. F2 meets the requirements of compressibility and hausner ratio, as well as hardness and brittleness. The results of the F1, F2, F4, and F5 solutions are eligible, while F3 is not. The conclusion of this study is that Avicel PH 102 is better at increasing the flow rate, compressibility, and hausner ratio than the pregelatinized starch of primary taro tubers. The five, requirements are met by this formula, including uniformity in weight, size and disintegration time. The use of Avicel PH 102 results in high hardness and low brittleness, while pregelatinized starch results in low hardness and high brittleness. F1, F2, F4, and F5 qualify for resolution, while F3 does not
Co-Authors Adita Silvia Fitriana Alfianto, Hazim Fikri Amanda, Yusi Lusiana Deva Krisna Kadarani Dina Febrina Dzakiyyatunnisa, Hanifah Fauziah Fauziah Fauziah Fionaliasti, Fionaliasti Firdaus, Anisa Kautsar Fitri, Ely Nurul Fitriyani, Gita Handayani, Wike Deni Setyo Ikhwan Yuda Kusuma Inayah, Somatul Khasanah, Khuswatun Kurniasih, Khamdiyah Indah Lestari, Kurni Ambar Maulana, Restu Ningtyas, Ichi Aprilia Nur Rahmawati Permatasari, Fenny Prabandari, Rani Pranbandari, Rani Pujianti, Ayu Putri, Arine Astika Rachmawati, Ira Samodra, Galih Siti Setianingsih Sumargo, Kukuh Yunianto Sunarti Suri, Natasha Triska Turnip, Monika Maristella Ulinnuha, Alvin Umayah, Dani Yatul Yuliani, Anis Fitria Yunita, Fadella Nur