As one of the most popular social media in Indonesia, Instagram has a significant opportunity to become a medium for information, education, and health promotion. Instagram allows users to search, share, and interact about current health issues. By distributing questionnaires to @pandemictalks followers based on simple random sampling technique, this study examines the effect of media use motives which include Seeking Information, Building Self-Agency, Social Interaction, Technological Convenience, Self Expression on active engagement. Based on the results of the regression analysis, it was found that Seeking Information, Technological Convenience, Self Expression were significant predictors of active engagement, while the rest had no significant effect. The results of this study contribute to studies of uses and gratifications on social media Instagram during the Covid-19 pandemic.
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